Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249341 | 0.91 | ROCK2 (0.59) | ROCK2ROCK1KDRCDC42BPASRC | |
| SCHEMBL3242746 | 0.91 | ROCK2 (0.58) | ROCK2ROCK1KDRCDC42BPA | |
| SCHEMBL3248162 | 0.91 | ROCK2 (0.57) | ROCK2ROCK1KDRCDC42BPASRC | |
| SCHEMBL3247209 | 0.88 | ROCK2 (0.52) | ROCK2ROCK1KDRCDC42BPAKIT | |
| SCHEMBL3241420 | 0.85 | ROCK2 (0.59) | ROCK2ROCK1KDRCDC42BPAMAPK14 | |
| SCHEMBL3247570 | 0.84 | ROCK2 (0.57) | ROCK2ROCK1KDRCDC42BPAMAPK14 | |
| SCHEMBL3129438 | 0.84 | ROCK2 (0.68) | ROCK2ROCK1KDRCDC42BPA | |
| SCHEMBL3246082 | 0.84 | ROCK2 (0.61) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL13390977 | 0.82 | ROCK2 (0.57) | ROCK2ROCK1KDRCDC42BPASRC | |
| SCHEMBL3124049 | 0.81 | ROCK2 (0.60) | ROCK2ROCK1KDRCDC42BPAKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |