Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3251643 | 0.93 | ROCK2 (0.45) | ROCK2SMN1; SMN2HPGDGAAROCK1 | |
| SCHEMBL3247209 | 0.88 | ROCK2 (0.52) | ROCK2ROCK1 | |
| SCHEMBL3127371 | 0.87 | ROCK2 (0.42) | ROCK2ROCK1 | |
| SCHEMBL3244463 | 0.86 | ROCK2 (0.42) | ROCK2ALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL3238931 | 0.85 | ROCK2 (0.44) | ROCK2ROCK1 | |
| SCHEMBL3248061 | 0.85 | ROCK2 (0.53) | ROCK2ROCK1 | |
| SCHEMBL3252660 | 0.84 | ROCK2 (0.49) | ROCK2ROCK1 | |
| SCHEMBL3248596 | 0.84 | ROCK2 (0.53) | ROCK2ROCK1 | |
| SCHEMBL3249574 | 0.83 | ROCK2 (0.49) | ROCK2ALDH1A1SMN1; SMN2USP2HPGD | |
| SCHEMBL3252024 | 0.83 | ROCK2 (0.50) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |