Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 15/20 | 0.59 |
| ▸ | CDC42BPA | Q5VT25 | 5/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249259 | 0.96 | ROCK2 (0.58) | ROCK2CDC42BPAROCK1ALDH1A1KDM4E | |
| SCHEMBL3241492 | 0.92 | ROCK2 (0.55) | ROCK2CDC42BPAROCK1ALDH1A1KDM4E | |
| SCHEMBL3247042 | 0.91 | ROCK2 (0.56) | ROCK2CDC42BPAROCK1ALDH1A1KDM4E | |
| SCHEMBL3245748 | 0.89 | ROCK2 (0.70) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL3129506 | 0.86 | ROCK2 (0.64) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL3249358 | 0.84 | ROCK2 (0.56) | ROCK2CDC42BPAROCK1KMT2AL3MBTL1 | |
| SCHEMBL13391340 | 0.83 | ROCK2 (0.67) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL3239731 | 0.83 | ROCK2 (0.60) | ROCK2CDC42BPAROCK1NPC1RAB9A | |
| SCHEMBL3243858 | 0.82 | ROCK2 (0.53) | ROCK2CDC42BPAROCK1KMT2ANPC1 | |
| SCHEMBL3239471 | 0.82 | ROCK2 (0.72) | ROCK2CDC42BPAROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |