Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 4/20 | 0.56 |
| ▸ | MTOR | P42345 | 3/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3596698 | 0.90 | PPARA (0.55) | FFAR1MTORPPARAPTGDR2CRHR1 | |
| SCHEMBL3099468 | 0.86 | KCNQ2 (0.55) | FFAR1MTORPPARAPTGDR2MEN1 | |
| SCHEMBL3609796 | 0.84 | P4HTM (0.50) | FFAR1PPARARAB9AMAPTNPC1 | |
| SCHEMBL3102103 | 0.83 | KCNQ2 (0.48) | FFAR1MTORPPARAPTGDR2HTT | |
| SCHEMBL3106591 | 0.82 | FFAR1 (0.46) | FFAR1MTORPPARAPTGDR2FFAR4 | |
| SCHEMBL3104820 | 0.82 | RAB9A (0.50) | FFAR1MTORPPARAEPHX2RAB9A | |
| SCHEMBL3605553 | 0.81 | FFAR1 (0.52) | FFAR1PPARAPTGDR2RAB9AMEN1 | |
| SCHEMBL3099035 | 0.81 | PPARA (0.51) | FFAR1MTORPPARAPTGDR2CRHR1 | |
| SCHEMBL3591356 | 0.79 | HIF1A (0.59) | FFAR1HTTLMNARAB9AMEN1 | |
| SCHEMBL19690431 | 0.77 | FFAR1 (0.58) | FFAR1MTORPPARAPTGDR2FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185149-A1 | USE OF KNCQ POTASSIUM CHANNEL OPENERS FOR REDUCING SYMPTOMS OF OR TREATING DISORDERS OR CONDITIONS WHEREIN THE DOPAMINERGIC SYSTEM IS DISRUPTED | H. Lundbeck A/S (DK) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009015667-A1 | USE OF KNCQ POTASSIUM CHANNEL OPENERS FOR REDUCING SYMPTOMS OF OR TREATING DISORDERS OR CONDITIONS WHEREIN THE DOPAMINERGIC SYSTEM IS DISRUPTED | H. LUNDBECK A/S (DK) | 2009-02-05 | — | — | WO | disclosed |