Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD44 | P16070 | 2/20 | 0.53 |
| ▸ | PNMT | P11086 | 7/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | RRM1 | P23921 | 1/20 | 0.36 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243586 | 0.87 | PNMT (0.55) | CD44PNMTMAOBPRCPADRA2A | |
| SCHEMBL14874208 | 0.83 | CD44 (0.53) | CD44PNMTMAOBPRCPADRA2A | |
| SCHEMBL5408570 | 0.83 | PNMT (0.58) | CD44PNMTMAOBPRCPADRA2A | |
| SCHEMBL14407965 | 0.83 | CD44 (0.53) | CD44PNMTMAOBPRCPADRA2A | |
| SCHEMBL11117006 | 0.78 | TTR (0.41) | PNMTKDM4E | |
| SCHEMBL4961562 | 0.75 | BCL2L1 (0.52) | KDM4E | |
| SCHEMBL7916810 | 0.75 | BCL2L1 (0.47) | KDM4E | |
| SCHEMBL5880562 | 0.75 | KMT2A (0.47) | CD44SCN9AKDM4E | |
| SCHEMBL28751491 | 0.74 | PNMT (0.52) | CD44PNMTMAOBADRA2AADRA2B | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL29883325 | 0.73 | PNMT (0.76) | CD44PNMTMAOBADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1227803-B1 | COMPOUNDS FOR INHIBITING IAPP-ASSOCIATED AMYLOID DEPOSITS | BELLUS HEALTH INTERNATIONAL LTD (CH) | 2010-05-05 | — | — | EP | claimed |
| US-6562836-B1 | Islet amyloid polypeptide (IAPP) is known to be capable of forming fibrils which are deposited in the pancreas of patients wtih type II diabetes | QUEEN'S UNIVERSITY OF KINGSTON (CA) | 2003-05-13 | — | — | US | claimed |