Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11777239 | 0.83 | MPO (0.44) | MPOMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL3264814 | 0.83 | MPO (0.47) | MPOMEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL3251975 | 0.82 | CYP3A4 (0.47) | MPOMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL22231837 | 0.80 | CYP1A2 (0.44) | MPOMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL6339844 | 0.79 | ALOX15 (0.58) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL28870145 | 0.79 | MPO (0.41) | MPOADCY10TAAR1CYP3A4ALOX15 | |
| SCHEMBL10515673 | 0.79 | TAAR1 (0.52) | MPOMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL4768466 | 0.79 | TBXA2R (0.50) | MEN1KMT2AALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL5006969 | 0.77 | CYP3A4 (0.62) | MPOMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL3254694 | 0.76 | CYP3A4 (0.52) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776347-B1 | SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI AVENTIS (FR) | 2010-05-26 | — | — | EP | disclosed |
| US-7396958-B2 | Sulphonamide derivatives, their preparation and their therapeutic application | SANOFI AVENTIS (FR) | 2008-07-08 | — | — | US | disclosed |
| US-20070185136-A1 | SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI-AVENTIS (FR) | 2007-08-09 | — | — | US | disclosed |
| EP-1776347-A1 | SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | Sanofi-Aventis (FR) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006024779-A1 | SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI-AVENTIS (FR) | 2006-03-09 | — | — | WO | disclosed |
| US-5792874-A | Process for the manufacture of 8-chloro-6-(2-flourophenyl)-1-methyl-4H-imidazo 1,5A! 1,4!benzodiazepine (midazolam) | RANBAXY LABORATORIES, LTD. (IN) | 1998-08-11 | — | — | US | disclosed |
| US-5756729-A | Process for the manufacture of 8-chloro-6 (2-fluorophenyl)-1 methyl-4H-imidazo 1,5a! 1,4! benzodiazepine (midazolam) | RANBAXY LABORATORIES, LTD. (IN) | 1998-05-26 | — | — | US | disclosed |
| EP-0835874-A2 | A process for the manufacture of 8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo (1,5a)(1,4) benzodiazepine (midazolam) | RANBAXY LABORATORIES, LTD. (IN) | 1998-04-15 | — | — | EP | disclosed |
| US-4281142-A | Imidazolecarboxaldehydes | HOFFMANN-LA ROCHE INC. (US) | 1981-07-28 | — | — | US | disclosed |
| EP-0017181-A1 | Process for the production of imidazobenzodiazepine derivatives, and intermediates for their production | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-10-15 | — | — | EP | disclosed |
| US-4194049-A | 2-[[2-Methyl-1-[2-benzoyl(or benzyl)phenyl]-1H-imidazol-5-yl]methyl]-1H-isoindole-1,3(2H)-diones | HOFFMANN-LA ROCHE INC. (US) | 1980-03-18 | — | — | US | disclosed |
| US-3992400-A | 1-(α-Phenyl-o-tolyl)imidazoles | THE UPJOHN COMPANY (US) | 1976-11-16 | — | — | US | disclosed |
| US-3941803-A | 2-(Imidazol-1-yl)benzophenones | THE UPJOHN COMPANY (US) | 1976-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185136-A1 | SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | HCRTR2, GIPR, SSTR2 | MPO 1260/4885MEN1 375/4885KMT2A 1181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.