Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | HK1 | P19367 | 1/20 | 0.57 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | DHFR | P00374 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3240367 | 0.82 | SORD (0.40) | NPC1RAB9AHK1HKDC1KDM4E | |
| SCHEMBL6664410 | 0.82 | KDM4E (0.51) | NPC1RAB9AHK1HKDC1KDM4E | |
| SCHEMBL3243362 | 0.78 | KDM4E (0.47) | NPC1RAB9AHK1HKDC1KDM4E | |
| SCHEMBL3244053 | 0.78 | KDM4E (0.46) | NPC1RAB9AHK1HKDC1KDM4E | |
| SCHEMBL3246409 | 0.77 | KDM4E (0.43) | NPC1RAB9AHK1HKDC1KDM4E | |
| SCHEMBL31254467 | 0.76 | NPC1 (0.59) | NPC1RAB9AHK1HKDC1KDM4E | |
| SCHEMBL3247999 | 0.76 | TNF (0.47) | NPC1RAB9AHK1HKDC1KDM4E | |
| SCHEMBL6783933 | 0.76 | MEN1 (0.46) | NPC1RAB9AKDM4EMAPTTSHR | |
| SCHEMBL3238433 | 0.76 | DHFR (0.42) | NPC1RAB9AHK1HKDC1KDM4E | |
| SCHEMBL5030785 | 0.75 | RAB9A (0.63) | NPC1RAB9AHK1HKDC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2140864-A2 | Use of GAL3 receptor antagonists for the treatment of depression and / or anxiety and compounds useful in such methods | H.Lundbeck A/S (DK) | 2010-01-06 | — | — | EP | disclosed |
| WO-2004034967-A2 | 2,4,6-TRIAMINOPYRIMIDINES FOR THE TREATMENT OF DEPRESSION AND/OR ANXIETY | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2004-04-29 | — | — | WO | disclosed |
| WO-2004014307-A2 | GAL3 ANTAGONISTS FOR THE TREATMENT OF NEUROPATHIC PAIN | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2004-02-19 | — | — | WO | disclosed |
| WO-2004014376-A1 | GAL3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF AFFECTIVE DISORDERS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2004-02-19 | — | — | WO | disclosed |
| EP-1363638-A2 | USE OF GAL3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF DEPRESSION AND/OR ANXIETY AND COMPOUNDS USEFUL IN SUCH METHODS | Synaptic Pharmaceutical Corporation (US) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002060392-A2 | USE OF GAL3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF DEPRESSION AND/OR ANXIETY AND COMPOUNDS USEFUL IN SUCH METHODS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2002-08-08 | — | — | WO | disclosed |