Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 17/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355986 | 0.83 | SCN9A (0.58) | SCN9AKCNH2CARM1PRMT6SCN5A | |
| SCHEMBL3123488 | 0.74 | SCN9A (0.83) | SCN9AKCNH2SCN5ASCN4ASCN3A | |
| SCHEMBL5596677 | 0.73 | CARM1 (0.45) | SCN9ATMEM97CARM1PRMT6SIGMAR1 | |
| SCHEMBL2881173 | 0.73 | SCN9A (0.44) | SCN9AKCNH2TMEM97CARM1PRMT6 | |
| SCHEMBL16652580 | 0.73 | KIT (0.58) | — | |
| SCHEMBL3240908 | 0.71 | SCN9A (1.00) | SCN9AKCNH2SCN5ASCN4ASCN3A | |
| SCHEMBL29563196 | 0.71 | CARM1 (0.48) | SCN9ATMEM97CARM1PRMT6SIGMAR1 | |
| SCHEMBL27158553 | 0.71 | NPC1 (0.59) | KCNH2TMEM97CARM1PRMT6SIGMAR1 | |
| SCHEMBL8551647 | 0.70 | SIGMAR1 (0.64) | TMEM97CARM1PRMT6SIGMAR1PRMT8 | |
| Hydrochloric Acid SCHEMBL8555397 | 0.69 | SIGMAR1 (0.62) | TMEM97CARM1PRMT6SIGMAR1PRMT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |