Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.51 |
| ▸ | ERN1 | O75460 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19127090 | 0.86 | ERN1 (0.57) | ERN1FYN | |
| SCHEMBL3246021 | 0.78 | TDP2 (0.44) | ERN1NPC1LMNAPKMPIK3CA | |
| SCHEMBL3247925 | 0.76 | KDR (0.42) | KMT2AMEN1NPC1RAB9AKDR | |
| SCHEMBL3240510 | 0.76 | KDR (0.45) | KMT2AMEN1ERN1LMNAALDH1A1 | |
| SCHEMBL13356451 | 0.75 | HDAC6 (0.49) | KMT2AMEN1RAB9AALDH1A1KDR | |
| SCHEMBL3262625 | 0.74 | RHOA (0.51) | KMT2AMEN1NPC1LMNAPKM | |
| SCHEMBL3242077 | 0.73 | CTSC (0.47) | EGFR | |
| SCHEMBL2542781 | 0.73 | KMT2A (0.49) | KMT2AMEN1PABPC1ERN1NPC1 | |
| SCHEMBL1375752 | 0.73 | PIK3CA (0.52) | KMT2AMEN1PABPC1NPC1PIK3CA | |
| SCHEMBL3262264 | 0.73 | TRIM24 (0.41) | KMT2AMEN1ERN1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |