Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 4/20 | 1.00 |
| ▸ | SLCO1B3 | Q9NPD5 | 4/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 4/20 | 1.00 |
| ▸ | SLCO2B1 | O94956 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | F2 | P00734 | 1/20 | 1.00 |
| ▸ | PLAU | P00749 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isosilybin A SCHEMBL972938 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Isosilybin A SCHEMBL18089487 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silybin B SCHEMBL751461 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL678427 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silybin A SCHEMBL23466786 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL24236664 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL19194836 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL22993978 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL22398934 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Isosilybin A SCHEMBL4653986 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8515 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122074593-A | Montmorillonite co-carried silymarin nano suspension and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122080093-A | Compounds effective in treating liver toxicity and fatty liver disease and uses thereof | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026107510-A1 | HOT-MELT ADHESIVE COMPOSITION AND METHOD OF APPLICATION | BIOBOND ADHESIVES, INC. (US) | 2026-05-21 | — | — | WO | claimed |
| CN-122059941-A | Method for purifying silymarin and method for preparing high-purity silybin | 福建广生堂药业股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122056926-A | Probiotic composition containing melatonin and application of composition in sleep | 南京北极光生物科技有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122031354-A | PH responsive composite microneedle and preparation method thereof | 苏大新材料发展(苏州)有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122030504-A | Application of silybin combined chenodeoxycholic acid in improving quality degradation of procambarus clarkia caused by zero fish meal feed | 广东海洋大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122031742-A | Starch film slow-release patch for promoting wound healing and preparation method thereof | 咸阳职业技术学院 | 2026-05-15 | — | — | CN | claimed |
| CN-122031365-A | Phenylborate hydrogel loaded with silibinin microspheres and preparation method and application thereof | 沈阳药科大学 | 2026-05-15 | — | — | CN | claimed |
| US-20260130395-A1 | Water Dispersible Botanical Compositions | AQUILA BLACK LTD (AU) | 2026-05-14 | — | — | US | claimed |
| EP-0299770-A2 | Soluble derivatives of silybin, a method of preparing them, and pharmaceutical compositions containing them | IDB HOLDING S.p.A. (IT) | 1989-01-18 | — | — | EP | claimed |
| EP-0289506-A1 | LIPOXYGENASE INHIBITORS | CHEMEX PHARMACEUTICALS, INC. (US) | 1988-11-09 | — | — | EP | claimed |
| US-4764508-A | Complexes of flavanolignans with phospholipids, preparation thereof and associated pharmaceutical compositions | INVERNI DELLA BEFFA S.P.A. (IT) | 1988-08-16 | — | — | US | claimed |
| WO-1988003800-A1 | LIPOXYGENASE INHIBITORS | CHEMEX PHARMACEUTICALS, INC. (US) | 1988-06-02 | — | — | WO | claimed |
| EP-0209037-A1 | Pharmaceutical compositions containing flavanolignanes and phospholipids as active principles | I D B HOLDING S.P.A. (IT) | 1987-01-21 | — | — | EP | claimed |
| EP-0209038-A1 | Complexes of flavanolignanes with phospholipids, preparation thereof and associated pharmaceutical compositions | I D B HOLDING S.P.A. (IT) | 1987-01-21 | — | — | EP | claimed |
| US-4617293-A | Flavonoid phosphate salts of aminoglycoside antibiotics | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1986-10-14 | — | — | US | claimed |
| US-4061765-A | LIVER DISORDERS | DR. MADAUS & CO. (DT) | 1977-12-06 | — | — | US | claimed |
| US-3997671-A | LIVER DISORDERS | DR. MADAUS & CO. (DT) | 1976-12-14 | — | — | US | claimed |
| US-3994925-A | USEFUL TO ANTAGONIZE OR MITIGATE LIVER DAMAGE AND INFLAMMATION | DR. MADAUS & CO. (DT) | 1976-11-30 | — | — | US | claimed |