Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 4/20 | 1.00 |
| ▸ | SLCO1B3 | Q9NPD5 | 4/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 4/20 | 1.00 |
| ▸ | SLCO2B1 | O94956 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | F2 | P00734 | 1/20 | 1.00 |
| ▸ | PLAU | P00749 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isosilybin A SCHEMBL18089487 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silybin B SCHEMBL751461 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL678427 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silybin A SCHEMBL23466786 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silybin A SCHEMBL324884 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL24236664 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL19194836 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL22993978 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL22398934 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Isosilybin A SCHEMBL4653986 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4617293-A | Flavonoid phosphate salts of aminoglycoside antibiotics | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1986-10-14 | — | — | US | claimed |
| CN-115721640-A | Application of isosilybin in preparing medicament for treating osteosarcoma | 中国科学院长春应用化学研究所 | 2023-03-03 | — | — | CN | disclosed |
| EP-2392326-B9 | Silibinin component for the treatment of hepatitis | MADAUS GMBH (DE) | 2018-09-05 | — | — | EP | disclosed |
| EP-3160483-B1 | MILK THISTLE EXTRACT OF FRUIT SHELLS OF SILYBUM MARIANUM, PROCESS OF MANUFACTURE AND USE | BIONORICA SE (DE) | 2018-02-28 | — | — | EP | disclosed |
| EP-2392326-B1 | Silibinin component for the treatment of hepatitis | MADAUS GMBH (DE) | 2018-01-24 | — | — | EP | disclosed |
| EP-3160483-A1 | MILK THISTLE EXTRACT FROM THE FRUIT PEELS OF MILK THISTLE, METHOD FOR PRODUCTION AND USE THEREOF | Bionorica SE (DE) | 2017-05-03 | — | — | EP | disclosed |
| EP-2430017-B1 | A method for preparing AMORPHOUS SILIBININ | MADAUS GMBH (DE) | 2016-06-29 | — | — | EP | disclosed |
| US-9248115-B2 | Silibinin component for the treatment of hepatitis | MADAUS GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-9248115-B2 | Silibinin component for the treatment of hepatitis | MADAUS GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| WO-2015197854-A1 | MILK THISTLE EXTRACT FROM THE FRUIT PEELS OF MILK THISTLE, METHOD FOR PRODUCTION AND USE THEREOF | BIONORICA SE (DE) | 2015-12-30 | — | — | WO | disclosed |
| US-20090041866-A1 | ABNORMAL PROTEIN REMOVING COMPOSITION | FANCL CORPORATION (JP) | 2009-02-12 | — | — | US | disclosed |
| EP-1845935-B1 | USE OF SILYMARINE AND/OR THE CONSTITUENTS THEREOF AS PROMOTERS OF THE PIGMENTATION OF THE SKIN OR HAIR | GREENPHARMA SAS (FR) | 2008-11-19 | — | — | EP | disclosed |
| US-20080033037-A1 | Utilisation de la silymarine et/ou de ses constituants comme agents promoteur de la pigmentation de la peau ou des cheveux | GREENPHARMA (FR) | 2008-02-07 | — | — | US | disclosed |
| EP-1813309-A1 | ABNORMAL PROTEIN REMOVING COMPOSITION | Fancl Corporation (JP) | 2007-08-01 | — | — | EP | disclosed |
| US-20060233738-A1 | Composition for promoting production of type 1 collagen and/or elastin | FANCL CORPORATION (JP) | 2006-10-19 | — | — | US | disclosed |
| CN-1679542-A | Frozen powder injection of silybin and its preparing method | LUYE NATURAL MEDICINE RES DEVE (CN) | 2005-10-12 | — | — | CN | disclosed |
| EP-1286706-A2 | GAMMA IRRADIATION OF PROTEIN-BASED PHARMACEUTICAL PRODUCTS | The American National Red Cross (US) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001087357-A2 | GAMMA IRRADIATION OF PROTEIN-BASED PHARMACEUTICAL PRODUCTS | THE AMERICAN NATIONAL RED CROSS (US) | 2001-11-22 | — | — | WO | disclosed |
| WO-1993025550-A1 | NOVEL BIOLOGICALLY ACTIVE EBURNAMENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | RICHETER GEDEON VEGYÉSZETI GYÁR RT. (HU) | 1993-12-23 | — | — | WO | disclosed |
| US-4617293-A | Flavonoid phosphate salts of aminoglycoside antibiotics | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1986-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033037-A1 | Utilisation de la silymarine et/ou de ses constituants comme agents promoteur de la pigmentation de la peau ou des cheveux | TES, NISCH, STMN2 | CYP3A4 1477/4885MAPT 2016/4885CYP2C9 2154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.