Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 4/20 | 1.00 |
| ▸ | SLCO1B3 | Q9NPD5 | 4/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 4/20 | 1.00 |
| ▸ | SLCO2B1 | O94956 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | F2 | P00734 | 1/20 | 1.00 |
| ▸ | PLAU | P00749 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isosilybin A SCHEMBL972938 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Isosilybin A SCHEMBL18089487 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL678427 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silybin A SCHEMBL23466786 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silybin A SCHEMBL324884 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL24236664 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL19194836 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL22993978 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL22398934 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Isosilybin A SCHEMBL4653986 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 425 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260091073-A1 | COMPOSITIONS CONTAINING SILYMARIN AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USING THE SAME | CYDEX PHARMACEUTICALS INC (US) | 2026-04-02 | — | — | US | claimed |
| EP-4663188-A1 | USE OF SILYBUM MARIANUM PHARMACEUTICAL COMPOSITION IN PREPARATION OF DRUGS FOR TREATING FATTY LIVER DISEASES | Health and Happiness (H&H) Hong Kong Limited (HK) | 2025-12-17 | — | — | EP | claimed |
| EP-4620534-A2 | COMPOSITIONS CONTAINING SILYMARIN AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USING THE SAME | CyDex Pharmaceuticals, Inc. (US) | 2025-09-24 | — | — | EP | claimed |
| US-12390506-B2 | Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same | CYDEX PHARMACEUTICALS, INC. (US) | 2025-08-19 | — | — | US | claimed |
| CN-116999431-B | Application of silybin in preparing medicines for preventing and/or treating proliferative vitreoretinopathy | 中山大学中山眼科中心 | 2025-05-23 | — | — | CN | claimed |
| EP-3939582-B1 | COMPOSITIONS CONTAINING SILYMARIN AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USING THE SAME | CYDEX PHARMACEUTICALS INC (US) | 2025-04-30 | — | — | EP | claimed |
| EP-4541351-A1 | COMPOUNDS AND COMBINATION AS STIMULATORS OF COLLAGEN SYNTHESIS | Center for Intelligent Research in Crystal Engineering, S.L. (ES) | 2025-04-23 | — | — | EP | claimed |
| CN-119770483-A | Application of pharmaceutical composition in preparation of medicine for treating neurodegenerative diseases | 合生元（广州）健康产品有限公司 | 2025-04-08 | — | — | CN | claimed |
| WO-2025024478-A1 | COMPOSITIONS FOR THE MODULATION OF TASTE | IXORA SCIENTIFIC INC. (US) | 2025-01-30 | — | — | WO | claimed |
| CN-112274547-B | Composition containing silybum marianum extract and fructose-1, 6-bisphosphate and application thereof in liver protection, sobering and fatigue resistance | 南京北极光生物科技有限公司 | 2024-12-27 | — | — | CN | claimed |
| US-20100055201-A1 | ANTI-PARASITIC METHODS AND COMPOSITIONS UTILIZING DIINDOLYLMETHANE-RELATED INDOLES | BIORESPONSE, L.L.C. | 2010-03-04 | — | — | US | claimed |
| WO-2009155887-A1 | COMPOSITION OF FLAVANOLIGNAN AND AMINO ACID WITH IMPROVED WATER SOLUBILITY | AGRA GROUP, A.S. (CZ) | 2009-12-30 | — | — | WO | claimed |
| CN-101565419-A | 7 and 20 dehydro-silybin dialky ether and preparation method and medicine use thereof | UNIV DALI (CN) | 2009-10-28 | — | — | CN | claimed |
| US-7563779-B2 | L-ergothioneine, milk thistle, and S-adenosylmethionine for the prevention, treatment and repair of liver damage | Nutramax Laboratories (US) | 2009-07-21 | — | — | US | claimed |
| WO-2008057253-A2 | ANTI-PARASITIC METHODS AND COMPOSITIONS UTILIZING DIINDOLYLMETHANE-RELATED INDOLES | BIORESPONSE, L.L.C. (US) | 2008-05-15 | — | — | WO | claimed |
| US-20070160688-A1 | Use of flavonoids to increase blood serum levels of dehydroepiandrosterone | PROPRIETARY WELLNESS, LLC | 2007-07-12 | — | — | US | claimed |
| US-20050129785-A1 | L-ergothioneine, milk thistle, and S-adenosylmethionine for the prevention, treatment and repair of liver damage | NUTRAMAX LABORATORIES, INC. (US) | 2005-06-16 | — | — | US | claimed |
| US-6863906-B2 | L-ergothioneine, milk thistle, and S-adenosylmethionine for the prevention, treatment and repair of liver damage | NUTRAMAX LABORATORIES, INC. (US) | 2005-03-08 | — | — | US | claimed |
| US-20020198169-A1 | L-ergothioneine, milk thistle, and S-adenosylmethionine for the prevention, treatment and repair of liver damage | HENDERSON TODD R (US) | 2002-12-26 | — | — | US | claimed |
| US-20010000472-A1 | L-ergothioneine, milk thistle, and s-adenosylmethionine for the prevention, treatment and repair of liver damage | NUTRAMAX LABORATORIES, INC. | 2001-04-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100055201-A1 | ANTI-PARASITIC METHODS AND COMPOSITIONS UTILIZING DIINDOLYLMETHANE-RELATED INDOLES | CASP3, IDO1, INMT | CYP3A4 2707/4885MAPT 4079/4885CYP2C9 2419/4885 |
| US-20070160688-A1 | Use of flavonoids to increase blood serum levels of dehydroepiandrosterone | SHBG, CYP17A1, HSD17B11 | CYP3A4 153/4885MAPT 3855/4885CYP2C9 343/4885 |
| US-12390506-B2 | Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same | GYS2, SDCBP, PYGL | CYP3A4 534/4885MAPT 2098/4885CYP2C9 812/4885 |
| US-20260091073-A1 | COMPOSITIONS CONTAINING SILYMARIN AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USING THE SAME | GYS2, COL1A1, COL14A1 | CYP3A4 605/4885MAPT 2626/4885CYP2C9 1061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.