Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 4/20 | 1.00 |
| ▸ | SLCO1B3 | Q9NPD5 | 4/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 4/20 | 1.00 |
| ▸ | SLCO2B1 | O94956 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | F2 | P00734 | 1/20 | 1.00 |
| ▸ | PLAU | P00749 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isosilybin A SCHEMBL972938 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Isosilybin A SCHEMBL18089487 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silybin B SCHEMBL751461 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL678427 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silybin A SCHEMBL23466786 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silybin A SCHEMBL324884 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL24236664 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL19194836 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Silibinin SCHEMBL22993978 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 | |
| Isosilybin A SCHEMBL4653986 | 1.00 | CYP3A4 (1.00) | CYP3A4MAPTCYP2C9SLCO1B3SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330019-A1 | EMULSION FORMULATIONS OF POORLY WATER-SOLUBLE COMPOUNDS | MENNING MARK MICHAEL (US) | 2023-10-19 | — | — | US | disclosed |
| US-20230330019-A1 | EMULSION FORMULATIONS OF POORLY WATER-SOLUBLE COMPOUNDS | MENNING MARK MICHAEL (US) | 2023-10-19 | — | — | US | disclosed |
| US-11306076-B2 | Silibinin lipoic acid ester with hepatoprotective activity and a method of preparing the same | XI'AN TAIKOMED PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2022-04-19 | — | — | US | disclosed |
| WO-2021234200-A1 | BINARY COMPLEX OF AN ORGANIC ZINC CHELATE AND FLAVONOIDS AND COMPOSITION COMPRISING IT FOR STIMULATING THE IMMUNE SYSTEM AND ENHANCING RESISTANCE TO VIRAL OR BACTERIAL INFECTIOUS DISEASES | UNIVERSIDAD DE VALLADOLID (ES) | 2021-11-25 | — | — | WO | disclosed |
| US-20210347767-A1 | SILIBININ LIPOIC ACID ESTER WITH HEPATOPROTECTIVE ACTIVITY AND A METHOD OF PREPARING THE SAME | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2021-11-11 | — | — | US | disclosed |
| US-20210171883-A1 | ANTIVIRAL WIPER | FUJIFILM CORPORATION (JP) | 2021-06-10 | — | — | US | disclosed |
| US-10766885-B1 | Silibinin 3,3′-thiodipropionic acid ester with hepatoprotective activity and a method of preparing the same | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2020-09-08 | — | — | US | disclosed |
| US-8569358-B2 | Use of silymarin and/or constituents thereof as skin or hair pigmentation promoters | GREENPHARMA (FR) | 2013-10-29 | — | — | US | disclosed |
| US-8569358-B2 | Use of silymarin and/or constituents thereof as skin or hair pigmentation promoters | GREENPHARMA (FR) | 2013-10-29 | — | — | US | disclosed |
| US-20080033037-A1 | Utilisation de la silymarine et/ou de ses constituants comme agents promoteur de la pigmentation de la peau ou des cheveux | GREENPHARMA (FR) | 2008-02-07 | — | — | US | disclosed |
| US-20080033037-A1 | Utilisation de la silymarine et/ou de ses constituants comme agents promoteur de la pigmentation de la peau ou des cheveux | GREENPHARMA (FR) | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210347767-A1 | SILIBININ LIPOIC ACID ESTER WITH HEPATOPROTECTIVE ACTIVITY AND A METHOD OF PREPARING THE SAME | FABP1, LIPC, FABP2 | CYP3A4 845/4885MAPT 4388/4885CYP2C9 900/4885 |
| US-20210171883-A1 | ANTIVIRAL WIPER | CGAS, PRKX, PDE4C | CYP3A4 4047/4885MAPT 4519/4885CYP2C9 4443/4885 |
| US-11306076-B2 | Silibinin lipoic acid ester with hepatoprotective activity and a method of preparing the same | FABP1, LIPC, FABP2 | CYP3A4 845/4885MAPT 4388/4885CYP2C9 900/4885 |
| US-20230330019-A1 | EMULSION FORMULATIONS OF POORLY WATER-SOLUBLE COMPOUNDS | CUTA, SUCLG1, TYR | CYP3A4 3078/4885MAPT 207/4885CYP2C9 614/4885 |
| US-10766885-B1 | Silibinin 3,3′-thiodipropionic acid ester with hepatoprotective activity and a method of preparing the same | FABP1, FABP2, TST | CYP3A4 292/4885MAPT 3998/4885CYP2C9 517/4885 |
| US-20080033037-A1 | Utilisation de la silymarine et/ou de ses constituants comme agents promoteur de la pigmentation de la peau ou des cheveux | TES, NISCH, STMN2 | CYP3A4 1477/4885MAPT 2016/4885CYP2C9 2154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.