Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3246027 | 1.00 | TTR (0.45) | TTRDPP4P2RY12NPC1CASP3 | |
| SCHEMBL3250273 | 0.92 | TTR (0.45) | TTRDPP4P2RY12NPC1CASP3 | |
| SCHEMBL3250274 | 0.92 | TTR (0.45) | TTRDPP4P2RY12NPC1CASP3 | |
| SCHEMBL4153013 | 0.85 | TTR (0.42) | TTRDPP4P2RY12NPC1CASP3 | |
| SCHEMBL3255449 | 0.84 | TTR (0.43) | TTRDPP4P2RY12NPC1CASP3 | |
| SCHEMBL3255436 | 0.82 | GABRA1 (0.45) | NPC1RAB9ACYP3A4MAPTKDM4E | |
| SCHEMBL3255440 | 0.82 | GABRA1 (0.45) | NPC1RAB9ACYP3A4MAPTKDM4E | |
| SCHEMBL3248495 | 0.81 | BCHE (0.35) | MAOBCYP3A4MAPTKDM4ELMNA | |
| SCHEMBL3251013 | 0.81 | GRIK1 (0.50) | NPC1RAB9AKDM4EGRIK1GRIA1 | |
| SCHEMBL3251008 | 0.81 | GRIK1 (0.50) | NPC1RAB9AKDM4EGRIK1GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |