Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3255154 | 0.89 | IP6K1 (0.39) | NPC1RAB9AMAPTALDH1A1KDM4E | |
| SCHEMBL3254619 | 0.84 | ALOX15 (0.44) | CYP3A4MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL3249364 | 0.84 | MEN1 (0.38) | MAPTALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL3250273 | 0.84 | TTR (0.45) | TTRDPP4P2RY12MAOBNPC1 | |
| SCHEMBL3250274 | 0.84 | TTR (0.45) | TTRDPP4P2RY12MAOBNPC1 | |
| SCHEMBL3248903 | 0.84 | TTR (0.45) | TTRDPP4P2RY12MAOBNPC1 | |
| SCHEMBL3246027 | 0.84 | TTR (0.45) | TTRDPP4P2RY12MAOBNPC1 | |
| SCHEMBL3248921 | 0.82 | ALDH1A1 (0.41) | MAPTALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL3245727 | 0.82 | GABRA1 (0.50) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL3252529 | 0.82 | ALDH1A1 (0.47) | NPC1RAB9AMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |