Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.35 |
| ▸ | ACHE | P22303 | 4/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253948 | 0.91 | GABRA1 (0.37) | BCHEACHEMAOAMAOBKDM4E | |
| SCHEMBL3248903 | 0.81 | TTR (0.45) | MAOBGRIK1GRIA1GRIA2GRIA3 | |
| SCHEMBL3246027 | 0.81 | TTR (0.45) | MAOBGRIK1GRIA1GRIA2GRIA3 | |
| SCHEMBL3248489 | 0.79 | MEN1 (0.41) | MAOBKDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL3248486 | 0.79 | MEN1 (0.41) | MAOBKDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL3251013 | 0.76 | GRIK1 (0.50) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3251008 | 0.76 | GRIK1 (0.50) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3250563 | 0.75 | MMP1 (0.49) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3250568 | 0.75 | MMP1 (0.49) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3250273 | 0.74 | TTR (0.45) | MAOBKDM4EALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |