Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | TDP2 | O95551 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 5/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254540 | 0.90 | MMP2 (0.46) | MMP2MMP13POLBALDH1A1GAA | |
| SCHEMBL3252205 | 0.89 | TTK (0.42) | MMP13SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL3250925 | 0.87 | NR1H2 (0.38) | SMN1; SMN2ALDH1A1CYP1A2TSHRCYP2D6 | |
| SCHEMBL3251203 | 0.86 | JAK3 (0.47) | MMP2MMP13POLBJAK3 | |
| SCHEMBL3249063 | 0.86 | CDK2 (0.39) | LMNATSHRBRD4 | |
| SCHEMBL3252380 | 0.86 | CSF1R (0.43) | SMN1; SMN2ALDH1A1LMNAGAACYP1A2 | |
| SCHEMBL3252050 | 0.85 | GAA (0.40) | ALDH1A1LMNAGAAJAK3HPGD | |
| SCHEMBL3243042 | 0.84 | CYP17A1 (0.41) | BRD4JAK3 | |
| SCHEMBL3249476 | 0.84 | ICMT (0.37) | SMN1; SMN2ALDH1A1LMNATP53GAA | |
| SCHEMBL3243041 | 0.84 | WEE1 (0.38) | MMP2POLBALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |