Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | BRD2 | P25440 | 3/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.39 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 4/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249186 | 1.00 | KDM4E (0.46) | KDM4EHSD17B10MEN1KMT2APOLB | |
| SCHEMBL3253429 | 0.89 | CASP3 (0.42) | KDM4EHSD17B10MEN1KMT2APOLB | |
| SCHEMBL13928187 | 0.89 | CASP3 (0.42) | KDM4EHSD17B10MEN1KMT2APOLB | |
| SCHEMBL4166331 | 0.87 | KDM4E (0.43) | KDM4EHSD17B10MEN1KMT2APOLB | |
| SCHEMBL4166329 | 0.87 | KDM4E (0.43) | KDM4EHSD17B10MEN1KMT2APOLB | |
| SCHEMBL3251417 | 0.83 | CASP3 (0.45) | KDM4EHSD17B10MEN1KMT2APOLB | |
| SCHEMBL13950965 | 0.82 | HTR7 (0.42) | KDM4EHSD17B10MEN1KMT2APOLB | |
| SCHEMBL3247163 | 0.82 | GAA (0.55) | KDM4EHSD17B10MEN1KMT2APOLB | |
| Propionic Acid SCHEMBL4173362 | 0.81 | KDM4E (0.45) | KDM4EHSD17B10MEN1KMT2APOLB | |
| Propionic Acid SCHEMBL4166334 | 0.81 | KDM4E (0.45) | KDM4EHSD17B10MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |