Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 10/20 | 0.38 |
| ▸ | CASP7 | P55210 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | BRD2 | P25440 | 3/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CASP9 | P55211 | 3/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | CASP2 | P42575 | 2/20 | 0.34 |
| ▸ | CASP4 | P49662 | 2/20 | 0.34 |
| ▸ | CASP6 | P55212 | 2/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4166329 | 1.00 | KDM4E (0.43) | KDM4EHSD17B10POLBPKMHTR7 | |
| SCHEMBL3249189 | 0.87 | KDM4E (0.46) | KDM4EHSD17B10POLBPKMHTR7 | |
| SCHEMBL3249186 | 0.87 | KDM4E (0.46) | KDM4EHSD17B10POLBPKMHTR7 | |
| SCHEMBL4170125 | 0.84 | KDM4E (0.47) | KDM4EHSD17B10POLBPKMMEN1 | |
| SCHEMBL3253429 | 0.81 | CASP3 (0.42) | KDM4EHSD17B10POLBPKMHTR7 | |
| SCHEMBL13928187 | 0.81 | CASP3 (0.42) | KDM4EHSD17B10POLBPKMHTR7 | |
| SCHEMBL3251417 | 0.81 | CASP3 (0.45) | KDM4EHSD17B10POLBPKMHTR7 | |
| Propionic Acid SCHEMBL4173362 | 0.80 | KDM4E (0.45) | KDM4EHSD17B10POLBPKMHTR7 | |
| Propionic Acid SCHEMBL4166334 | 0.80 | KDM4E (0.45) | KDM4EHSD17B10POLBPKMHTR7 | |
| SCHEMBL13950965 | 0.79 | HTR7 (0.42) | KDM4EHSD17B10POLBPKMHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | claimed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | claimed |
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | disclosed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | MAP3K1, MAP3K2, MAP3K7 | KDM4E 1970/4885HSD17B10 3847/4885POLB 1007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.