SCHEMBL3249233

SCHEMBL3249233

COc1ccc2c(c1)CN(C(=O)Cn1c(=O)n(C)c3cc(-c4cccc(Cl)c4)cnc31)C2

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRIN2B Q13224 20/20 0.61
GRIN1 Q05586 18/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3256125 0.93 GRIN2B (0.55) GRIN2BGRIN1
SCHEMBL3242733 0.93 GRIN1 (0.50) GRIN2BGRIN1
SCHEMBL3245322 0.89 GRIN1 (0.51) GRIN2BGRIN1
SCHEMBL3252351 0.89 GRIN2B (0.52) GRIN2BGRIN1
SCHEMBL3245549 0.86 GRIN1 (0.46) GRIN2BGRIN1
SCHEMBL3236751 0.86 GRIN1 (0.46) GRIN2BGRIN1
SCHEMBL3252047 0.85 GRIN1 (0.46) GRIN2BGRIN1
SCHEMBL3250701 0.83 HSD17B10 (0.44) GRIN2BGRIN1
SCHEMBL13521617 0.82 GRIN1 (0.58) GRIN2BGRIN1
SCHEMBL3247035 0.82 GRIN2B (0.47) GRIN2BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010008777-A2 FUSED AZABICYCLIC PYRIDINES LIGAND PHARMACEUTICALS INC. (US) 2010-01-21 WO claimed