Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.37 |
| ▸ | PTPRB | P23467 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252131 | 0.84 | ALDH1A1 (0.44) | GPR119ALDH1A1LMNAMAPTHSD17B10 | |
| SCHEMBL3250607 | 0.83 | GPR119 (0.38) | GPR119ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL632936 | 0.80 | GPR119 (0.47) | GPR119ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL5454076 | 0.79 | GPR119 (0.41) | GPR119LMNATP53THRBPOLB | |
| SCHEMBL6977617 | 0.72 | MEN1 (0.39) | GPR119ALDH1A1MAPTHPGDUSP30 | |
| SCHEMBL5186931 | 0.72 | MEN1 (0.39) | GPR119ALDH1A1MAPTHPGDUSP30 | |
| SCHEMBL3246480 | 0.72 | NR1H2 (0.41) | GPR119ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL3244534 | 0.72 | NR1H2 (0.41) | GPR119ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL426434 | 0.70 | NR1H2 (0.39) | GPR119ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL6217654 | 0.70 | HPGD (0.40) | GPR119ALDH1A1MAPTHPGDUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799674-B1 | NEW PIPERIDINE ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-05-05 | — | — | EP | disclosed |
| EP-1799674-A1 | NEW PIPERIDINE ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006038172-A1 | NEW PIPERIDINE ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-04-13 | — | — | WO | disclosed |