Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.40 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.40 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.40 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.40 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.40 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.40 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.40 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.40 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5655091 | 0.87 | KDM4E (0.55) | KDM4EHTTHSD17B3ALDH1A1HPGD | |
| SCHEMBL5653132 | 0.87 | KDM4E (0.55) | KDM4EHTTHSD17B3ALDH1A1HPGD | |
| SCHEMBL7599990 | 0.81 | P2RX7 (0.48) | ALDH1A1CES2 | |
| SCHEMBL18704817 | 0.76 | TP53 (0.42) | KDM4EHTTALDH1A1MAPTLMNA | |
| SCHEMBL1744701 | 0.75 | CA12 (0.47) | KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL27480140 | 0.74 | ESR2 (0.42) | HTTSMN1; SMN2 | |
| SCHEMBL5142259 | 0.74 | TP53 (0.44) | KDM4EHTTALDH1A1MAPTLMNA | |
| SCHEMBL10938970 | 0.74 | TP53 (0.44) | KDM4EHTTALDH1A1MAPTLMNA | |
| SCHEMBL27980958 | 0.73 | ALDH1A1 (0.49) | KDM4EHTTALDH1A1MAPTCES2 | |
| SCHEMBL10945234 | 0.72 | ESR1 (0.42) | KDM4EHTTALDH1A1HPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1315709-B1 | AMINOALKYLBENZOYL-BENZOFURAN OR BENZOTHIOPHENE DERIVATIVES, METHOD FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2010-05-26 | — | — | EP | disclosed |
| EP-1315709-A1 | AMINOALKYLBENZOYL-BENZOFURAN OR BENZOTHIOPHENE DERIVATIVES, METHOD FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAME | Sanofi-Aventis (FR) | 2003-06-04 | — | — | EP | disclosed |
| WO-2002016339-A1 | AMINOALKYLBENZOYL-BENZOFURAN OR BENZOTHIOPHENE DERIVATIVES, METHOD FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2002-02-28 | — | — | WO | disclosed |