Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.37 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.37 |
| ▸ | MPL | P40238 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249304 | 0.87 | NR4A2 (0.48) | CYP1A2HSD17B10NR4A2GRIK1GRIK2 | |
| SCHEMBL3248372 | 0.85 | CDK4 (0.43) | CYP1A2HSD17B10NR4A2GRIK1GRIK2 | |
| SCHEMBL3247597 | 0.84 | MCL1 (0.46) | CYP1A2HSD17B10NR4A2GRIK1GRIK2 | |
| SCHEMBL3245608 | 0.83 | ACMSD (0.48) | CYP1A2HSD17B10NR4A2GRIK1GRIK2 | |
| SCHEMBL4153796 | 0.83 | TRIM24 (0.39) | TRIM24TRIM33AXLPARP1GRIN2D | |
| SCHEMBL3249242 | 0.82 | XDH (0.49) | CYP1A2HSD17B10NR4A2GRIK1GRIK2 | |
| SCHEMBL3242761 | 0.81 | CAMKK2 (0.46) | CYP1A2HSD17B10NR4A2GRIK1GRIK2 | |
| SCHEMBL3250737 | 0.81 | CYP1A2 (0.41) | CYP1A2HSD17B10NR4A2GRIK1GRIK2 | |
| SCHEMBL3241765 | 0.80 | NR4A2 (0.53) | NR4A2 | |
| SCHEMBL3249950 | 0.80 | DHODH (0.47) | PARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |