Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.47 |
| ▸ | DHFR | P00374 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3246827 | 0.90 | DHFR (0.46) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL3247150 | 0.87 | TUBB4A (0.42) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL3246894 | 0.86 | DHFR (0.44) | GPR84DHFRMEN1SLC22A1ALDH1A1 | |
| SCHEMBL5657904 | 0.84 | DHFR (0.54) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL3254525 | 0.84 | DHFR (0.45) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL3255329 | 0.81 | SMN1; SMN2 (0.40) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL3248694 | 0.81 | SMN1; SMN2 (0.38) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL5657350 | 0.80 | DHFR (0.50) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL5658141 | 0.80 | DHFR (0.55) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL5658323 | 0.80 | DHFR (0.55) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651639-B1 | BENZOFURAN DERIVATIVES AND THEIR USE IN THE TREATMENT OF MICROBIAL INFECTIONS | ARPIDA AG (CH) | 2010-05-26 | — | — | EP | claimed |
| US-7524854-B2 | Benzofuran derivatives and their use in the treatment of microbial infections | ARPIDA AG (CH) | 2009-04-28 | — | — | US | claimed |
| US-20060154943-A1 | Benzofuran derivatives and their use in the treatment of microbial infections | ARPIDA AG (CH) | 2006-07-13 | — | — | US | claimed |
| EP-1651639-A1 | BENZOFURAN DERIVATIVES AND THEIR USE IN THE TREATMENT OF MICROBIAL INFECTIONS | Arpida AG, (CH) | 2006-05-03 | — | — | EP | claimed |
| WO-2005005418-A1 | BENZOFURAN DERIVATIVES AND THEIR USE IN THE TREATMENT OF MICROBIAL INFECTIONS | ARPIDA AG (CH) | 2005-01-20 | — | — | WO | claimed |
| EP-1651639-B1 | BENZOFURAN DERIVATIVES AND THEIR USE IN THE TREATMENT OF MICROBIAL INFECTIONS | ARPIDA AG (CH) | 2010-05-26 | — | — | EP | disclosed |
| US-7524854-B2 | Benzofuran derivatives and their use in the treatment of microbial infections | ARPIDA AG (CH) | 2009-04-28 | — | — | US | disclosed |
| US-20060154943-A1 | Benzofuran derivatives and their use in the treatment of microbial infections | ARPIDA AG (CH) | 2006-07-13 | — | — | US | disclosed |
| EP-1651639-A1 | BENZOFURAN DERIVATIVES AND THEIR USE IN THE TREATMENT OF MICROBIAL INFECTIONS | Arpida AG, (CH) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005005418-A1 | BENZOFURAN DERIVATIVES AND THEIR USE IN THE TREATMENT OF MICROBIAL INFECTIONS | ARPIDA AG (CH) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060154943-A1 | Benzofuran derivatives and their use in the treatment of microbial infections | DCXR, NLRP3, NISCH | MTNR1A 3908/4885GPR84 3707/4885DHFR 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.