Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 15/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.44 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249281 | 0.89 | ROCK2 (0.55) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL3241665 | 0.85 | ROCK2 (0.69) | ROCK2ROCK1 | |
| SCHEMBL3239730 | 0.82 | ROCK2 (0.59) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL3250291 | 0.82 | ROCK2 (0.74) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL3255236 | 0.82 | NPC1 (0.46) | ROCK2NPC1RAB9AMGLLTACR3 | |
| SCHEMBL13391233 | 0.82 | ROCK2 (0.72) | ROCK2ROCK1 | |
| SCHEMBL3241298 | 0.81 | ROCK2 (0.55) | ROCK2NPC1RAB9AROCK1MYLK4 | |
| SCHEMBL3244746 | 0.81 | ROCK2 (0.57) | ROCK2ROCK1 | |
| SCHEMBL3241905 | 0.80 | ROCK2 (0.60) | ROCK2ROCK1 | |
| SCHEMBL3248274 | 0.78 | ROCK2 (1.00) | ROCK2ROCK1MYLK4MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |