Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 4/20 | 0.49 |
| ▸ | MMP2 | P08253 | 4/20 | 0.49 |
| ▸ | MMP9 | P14780 | 4/20 | 0.49 |
| ▸ | GSK3B | P49841 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250568 | 1.00 | MMP1 (0.49) | MMP1MMP2MMP9GSK3BALDH1A1 | |
| SCHEMBL14623782 | 0.89 | MMP1 (0.49) | MMP1MMP2MMP9GSK3BALDH1A1 | |
| SCHEMBL3249071 | 0.89 | ALOX15 (0.49) | MMP1MMP2MMP9GSK3BALDH1A1 | |
| SCHEMBL3249067 | 0.89 | ALOX15 (0.49) | MMP1MMP2MMP9GSK3BALDH1A1 | |
| SCHEMBL4162578 | 0.85 | MMP1 (0.46) | MMP1MMP2MMP9GSK3BALDH1A1 | |
| SCHEMBL3251008 | 0.83 | GRIK1 (0.50) | KDM4ECYP1A2HDAC1HDAC3HDAC4 | |
| SCHEMBL3251013 | 0.83 | GRIK1 (0.50) | KDM4ECYP1A2HDAC1HDAC3HDAC4 | |
| SCHEMBL3248486 | 0.83 | MEN1 (0.41) | ALDH1A1KDM4ENPSR1TP53CYP1A2 | |
| SCHEMBL3248489 | 0.83 | MEN1 (0.41) | ALDH1A1KDM4ENPSR1TP53CYP1A2 | |
| SCHEMBL3254619 | 0.82 | ALOX15 (0.44) | MMP1MMP2MMP9GSK3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |