Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3248489 | 1.00 | MEN1 (0.41) | MEN1KMT2AHDAC3HDAC6MAOB | |
| SCHEMBL3253944 | 0.90 | SMN1; SMN2 (0.38) | MEN1KMT2AHDAC3HDAC6MAOB | |
| SCHEMBL3253941 | 0.90 | SMN1; SMN2 (0.38) | MEN1KMT2AHDAC3HDAC6MAOB | |
| SCHEMBL4155737 | 0.87 | MEN1 (0.43) | MEN1KMT2AHDAC3HDAC6MAOB | |
| SCHEMBL3249364 | 0.83 | MEN1 (0.38) | MEN1KMT2AHDAC3HDAC6MAPT | |
| SCHEMBL3250563 | 0.83 | MMP1 (0.49) | MEN1KMT2AHDAC3HDAC6SMN1; SMN2 | |
| SCHEMBL3250568 | 0.83 | MMP1 (0.49) | MEN1KMT2AHDAC3HDAC6SMN1; SMN2 | |
| Propionic Acid SCHEMBL4155740 | 0.80 | MEN1 (0.40) | MEN1KMT2AHDAC3HDAC6MAPT | |
| SCHEMBL3248903 | 0.79 | TTR (0.45) | MEN1KMT2AMAOBPTGS2MAPT | |
| SCHEMBL3246027 | 0.79 | TTR (0.45) | MEN1KMT2AMAOBPTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |