Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | USP9X | Q93008 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 2/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250055 | 0.85 | POLB (0.43) | PARP1POLBMEN1KMT2ACYP1A2 | |
| SCHEMBL3245352 | 0.82 | HTR2C (0.42) | PARP1POLBMEN1KMT2ACYP1A2 | |
| SCHEMBL3250699 | 0.81 | KDM4E (0.39) | PARP1POLBMEN1KMT2AHSD17B10 | |
| SCHEMBL3248398 | 0.81 | POLB (0.40) | PARP1POLBMEN1KMT2ACYP1A2 | |
| SCHEMBL4153191 | 0.76 | ACACB (0.42) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL3254470 | 0.76 | PKM (0.53) | PARP1POLBTDP1MAPTTP53 | |
| SCHEMBL3243012 | 0.75 | PARG (0.56) | POLBMEN1KMT2AHSD17B10LMNA | |
| SCHEMBL3245344 | 0.75 | PTPN11 (0.54) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL3247192 | 0.75 | PTPN11 (0.56) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL3252130 | 0.75 | TAS2R14 (0.50) | PARP1POLBMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |