Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 13/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 12/20 | 0.56 |
| ▸ | PTPN6 | P29350 | 11/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245344 | 0.84 | PTPN11 (0.54) | PTPN11PTPN1PTPN6POLBMEN1 | |
| SCHEMBL3242717 | 0.84 | ALDH1A1 (0.54) | POLBMEN1CYP1A2KMT2AHSD17B10 | |
| SCHEMBL3251641 | 0.81 | BRD4 (0.61) | MAPT | |
| SCHEMBL3250055 | 0.81 | POLB (0.43) | PTPN11PTPN1PTPN6MCL1POLB | |
| SCHEMBL3249998 | 0.80 | POLB (0.47) | POLBMEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL3249991 | 0.79 | BRD4 (0.50) | MCL1POLBMAPT | |
| SCHEMBL3252130 | 0.79 | TAS2R14 (0.50) | PTPN11POLBMEN1CYP1A2CYP2C9 | |
| SCHEMBL3249438 | 0.78 | PTPN11 (0.45) | PTPN11POLBMEN1CYP1A2CYP2C9 | |
| SCHEMBL3247788 | 0.78 | DAO (0.46) | POLBMEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL3254470 | 0.78 | PKM (0.53) | POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | claimed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |