Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 5/20 | 0.41 |
| ▸ | RHOA | P61586 | 4/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18487074 | 0.92 | GRM5 (0.43) | NTRK1GRM5RHOASIRT5ALDH1A1 | |
| SCHEMBL304191 | 0.89 | LMNA (0.37) | NTRK1RHOAALDH1A1HPGDGAA | |
| SCHEMBL18487077 | 0.86 | LMNA (0.46) | RHOAALDH1A1HPGDGAALMNA | |
| SCHEMBL3379922 | 0.81 | GRM5 (0.60) | NTRK1GRM5RHOASIRT5ALDH1A1 | |
| SCHEMBL3415407 | 0.80 | HSD11B1 (0.45) | NTRK1ALDH1A1KMT2A | |
| SCHEMBL2214180 | 0.77 | MEN1 (0.54) | ALDH1A1LMNAKMT2A | |
| SCHEMBL3377043 | 0.76 | MEN1 (0.47) | GRM5ALDH1A1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL302949 | 0.76 | MEN1 (0.49) | ALDH1A1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL2214837 | 0.76 | MEN1 (0.44) | ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL303294 | 0.75 | MEN1 (0.47) | GRM5ALDH1A1GAAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | disclosed |