Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254539 | 0.90 | MAPT (0.48) | MAPTKDM4EHPGDHSD17B10USP2 | |
| SCHEMBL3252256 | 0.89 | MAPT (0.44) | MAPTKDM4EHPGDHSD17B10USP2 | |
| SCHEMBL3249025 | 0.85 | MAPT (0.52) | MAPTKDM4EHPGDHSD17B10USP2 | |
| SCHEMBL3254915 | 0.84 | MAPT (0.47) | MAPTKDM4EHPGDHSD17B10USP2 | |
| SCHEMBL3249920 | 0.84 | GABRA1 (0.47) | MAPTKDM4EHSD17B10POLBGABRA1 | |
| SCHEMBL3241904 | 0.83 | KDM4E (0.46) | MAPTKDM4EHPGDHSD17B10USP2 | |
| SCHEMBL3247541 | 0.82 | MEN1 (0.44) | MAPTKDM4EHPGDHSD17B10USP2 | |
| SCHEMBL3250657 | 0.82 | CRHBP (0.49) | MAPTKDM4EHPGDHSD17B10USP2 | |
| SCHEMBL3251817 | 0.82 | CRHBP (0.49) | MAPTKDM4EHPGDHSD17B10USP2 | |
| SCHEMBL3242035 | 0.82 | GABRA1 (0.45) | MAPTKDM4EHPGDHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |