Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 4/20 | 0.31 |
| ▸ | HTR2C | P28335 | 4/20 | 0.31 |
| ▸ | HRH1 | P35367 | 4/20 | 0.31 |
| ▸ | HTR2B | P41595 | 4/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29493251 | 0.86 | HDAC3 (0.41) | HDAC3HSD17B3NAMPTMAPK1HSP90AA1 | |
| SCHEMBL15056964 | 0.86 | HDAC3 (0.41) | HDAC3HSD17B3NAMPTMAPK1HSP90AA1 | |
| SCHEMBL15056675 | 0.83 | HDAC3 (0.36) | HDAC3HSD17B3P2RX4NAMPTMAPK1 | |
| SCHEMBL5721697 | 0.82 | ALDH1A1 (0.41) | HDAC3HSD17B3P2RX4NAMPTMAPK1 | |
| SCHEMBL323681 | 0.82 | MAPK1 (0.45) | HDAC3HSD17B3NAMPTMAPK1NR1H2 | |
| SCHEMBL15056981 | 0.81 | HDAC3 (0.35) | HDAC3HSD17B3P2RX4NAMPTHTR2A | |
| SCHEMBL323769 | 0.81 | TSHR (0.42) | HDAC3HSD17B3P2RX4NAMPT | |
| SCHEMBL324125 | 0.81 | P2RX4 (0.53) | HDAC3HSD17B3P2RX4NAMPTMEN1 | |
| SCHEMBL324190 | 0.80 | BCHE (0.44) | HDAC3NAMPTMAPK1MEN1KMT2A | |
| SCHEMBL3628702 | 0.80 | P2RX4 (0.46) | HDAC3HSD17B3P2RX4NAMPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590944-A1 | 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | Actelion Pharmaceuticals Ltd. (CH) | 2013-05-15 | — | — | EP | disclosed |
| US-20130109685-A1 | 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-05-02 | — | — | US | disclosed |
| WO-2012004722-A1 | 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109685-A1 | 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | PTGER1, PTGDR, PTGDR2 | HDAC3 2109/4885HSD17B3 967/4885DPP8 3814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.