Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL915160 | 0.88 | VCP (0.43) | KMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL915159 | 0.88 | VCP (0.43) | KMT2AALDH1A1SMN1; SMN2MEN1 | |
| Bicarbonate SCHEMBL3256726 | 0.86 | LMNA (0.54) | TDP1EPHX1KMT2AALDH1A1OPRK1 | |
| SCHEMBL4347373 | 0.85 | LMNA (0.55) | TDP1EPHX1KMT2AALDH1A1OPRK1 | |
| Acetic Acid SCHEMBL4754474 | 0.83 | LMNA (0.53) | TDP1EPHX1KMT2AALDH1A1OPRK1 | |
| Bicarbonate SCHEMBL3255892 | 0.81 | LMNA (0.51) | TDP1EPHX1KMT2AALDH1A1OPRK1 | |
| Bicarbonate SCHEMBL3258777 | 0.77 | CTSK (0.45) | TDP1EPHX1ALDH1A1OPRK1L3MBTL1 | |
| Bicarbonate SCHEMBL3254172 | 0.76 | CTSK (0.44) | TDP1EPHX1OPRK1L3MBTL1CYP2D6 | |
| Bicarbonate SCHEMBL3253206 | 0.76 | CTSK (0.44) | TDP1EPHX1OPRK1L3MBTL1CYP2D6 | |
| Bicarbonate SCHEMBL3256781 | 0.76 | CTSK (0.44) | TDP1EPHX1OPRK1L3MBTL1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919859-B1 | ACYLOXYALKYL CARBAMATE PRODRUGS OF TRANEXAMIC ACID AND USE | XENOPORT INC (US) | 2010-06-02 | — | — | EP | claimed |