Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 13/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 13/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 13/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 13/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 13/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 13/20 | 0.38 |
| ▸ | SCN1A | P35498 | 4/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.38 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253281 | 0.86 | SCN1A (0.44) | SCN1ASCN5ASCN8A | |
| SCHEMBL3258919 | 0.82 | GAA (0.41) | SCN1ASCN5ASCN8A | |
| SCHEMBL3256058 | 0.81 | MEP1B (0.42) | SCN1ASCN5ASCN8A | |
| SCHEMBL3257453 | 0.81 | SCN8A (0.40) | SCN1ASCN5ASCN8AAKR1C3AKR1C2 | |
| SCHEMBL3255525 | 0.80 | SCN8A (0.44) | SCN1ASCN5ASCN8A | |
| SCHEMBL3255842 | 0.80 | NMT1 (0.43) | SCN1ASCN5ASCN8APFKFB4 | |
| SCHEMBL3256685 | 0.79 | SCN8A (0.37) | SCN1ASCN5ASCN8APFKFB4 | |
| SCHEMBL3256693 | 0.79 | ACLY (0.40) | SCN1ASCN5ASCN8A | |
| SCHEMBL3259074 | 0.77 | HTT (0.49) | SCN1ASCN5ASCN8A | |
| SCHEMBL3259225 | 0.77 | TDP1 (0.45) | SCN1ASCN5ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2010-05-26 | — | — | EP | claimed |