Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SCN1A | P35498 | 3/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.45 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3258919 | 0.88 | GAA (0.41) | HTTSCN1ASCN5ASCN8AHSD11B1 | |
| SCHEMBL3253952 | 0.87 | MEN1 (0.48) | HTTSCN1ASCN5ASCN8AHSD11B1 | |
| SCHEMBL3248733 | 0.87 | HSD11B1 (0.51) | SCN1ASCN5ASCN8AHSD11B1ITGAV | |
| SCHEMBL3256119 | 0.86 | SCN8A (0.40) | HTTSCN1ASCN5ASCN8AHSD11B1 | |
| SCHEMBL3255525 | 0.85 | SCN8A (0.44) | SCN1ASCN5ASCN8AHSD11B1PIK3CA | |
| SCHEMBL3255395 | 0.85 | KCNA5 (0.46) | HTTALDH1A1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL3258667 | 0.84 | SLC22A12 (0.46) | SCN1ASCN5ASCN8AALDH1A1AKT1 | |
| SCHEMBL3259023 | 0.83 | L3MBTL1 (0.41) | HTTSCN1ASCN5ASCN8AHSD11B1 | |
| SCHEMBL3259225 | 0.83 | TDP1 (0.45) | SCN1ASCN5ASCN8AHSD11B1CDK1 | |
| SCHEMBL3255776 | 0.82 | RAB9A (0.43) | SCN1ASCN5ASCN8APIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2010-05-26 | — | — | EP | claimed |