SCHEMBL3256606

SCHEMBL3256606

CCOC(=O)C1Cc2cc(Cl)ccc2N1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.42
MAPK1 P28482 1/20 0.42
ALDH1A1 P00352 2/20 0.42
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
MAPT P10636 2/20 0.41
TSHR P16473 1/20 0.41
RAB9A P51151 1/20 0.40
ATM Q13315 1/20 0.40
PSEN1 P49768 1/20 0.40
PSEN2 P49810 1/20 0.40
APH1B Q8WW43 1/20 0.40
NCSTN Q92542 1/20 0.40
APH1A Q96BI3 1/20 0.40
PSENEN Q9NZ42 1/20 0.40
MAOB P27338 1/20 0.40
KDM4E B2RXH2 1/20 0.40
GAA P10253 1/20 0.40
HPGD P15428 1/20 0.40
HSD17B10 Q99714 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10909269 0.88 GAA (0.40) MAPK1ALDH1A1MEN1KMT2AMAPT
SCHEMBL10256197 0.86 MEN1 (0.41) MAPK1ALDH1A1MEN1KMT2AMAPT
SCHEMBL3256076 0.85 PDE5A (0.41) ALDH1A1MEN1KMT2AMAPTGAA
SCHEMBL5563634 0.85 PDE5A (0.41) ALDH1A1MEN1KMT2AMAPTGAA
SCHEMBL11956678 0.84 TNF (0.41) LMNAMAPK1ALDH1A1MEN1KMT2A
SCHEMBL3257026 0.84 ALDH1A1 (0.42) MAPK1ALDH1A1MEN1KMT2AMAPT
SCHEMBL862757 0.84 MEN1 (0.49) MAPK1ALDH1A1MEN1KMT2AMAPT
SCHEMBL3250596 0.83 ALOX15 (0.43) LMNAMAPK1ALDH1A1MEN1KMT2A
SCHEMBL27677025 0.81 SMN1; SMN2 (0.39) LMNAMAPK1ALDH1A1MEN1KMT2A
SCHEMBL13540058 0.81 GAA (0.41) MAPK1ALDH1A1MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101842376-A Tetracyclic indole derivatives and being used for the treatment of or prophylaxis of viral infections SCHERING CORP 2010-09-22 CN disclosed
EP-1330454-B1 BENZOPYRANYL HETEROCYCLE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DONGBU HITEK CO LTD (KR) 2010-05-19 EP disclosed
EP-1330454-A4 BENZOPYRANYL HETEROCYCLE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DONGBU HANNONG CHEMICAL CO LTD (KR) 2008-03-19 EP disclosed
EP-1330454-A1 BENZOPYRANYL HETEROCYCLE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Dongbu Hannong Chemical Co., Ltd. (KR) 2003-07-30 EP disclosed
CN-1089765-C 1H-pyrido [3,4-b] indole-4-carboxamide derivatives, preparation and application thereof in therapeutics SANOFI SYNTHESIZING LAB (FR) 2002-08-28 CN disclosed
US-6413983-B1 COUPLING EPOXIDE WITH INDOLE OR QUINOLINE COMPOUND; PROTECT-ING HEART, BRAIN, RETINA AND NEURONAL CELL FROM ?ISCHEMIA-REPERFUSION? INJURY; SUPPRESSING LIPID PEROXIDATION DONGBU HANNONG CHEMICAL CO. LTD. (KR) 2002-07-02 US disclosed
WO-2002030925-A1 BENZOPYRANYL HETEROCYCLE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DONGBU HANNONG CHEMICAL CO., LTD (KR) 2002-04-18 WO disclosed
US-6335360-B1 INDOLINE-2-CARBOXYLIC AMIDE DERIVATIVES; OBESITY, EATING AND PSYCHOLOGICAL DISORDERS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2002-01-01 US disclosed
CN-1233248-A 1H-pyrido [3,4-b] indole-4-carboxamide derivatives, preparation and application thereof in therapeutics SYNTHELABO (FR) 1999-10-27 CN disclosed
EP-0024852-B1 2,3-DIHYDRO-1H-INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES AND THEIR PREPARATION AMERICAN HOME PRODUCTS CORPORATION (US) 1986-09-03 EP disclosed
US-4454292-A CHEMICAL INTERMEDIATES OF ANGIOTENSIN CONVERTING ENZYNE INHIBITORS AMERICAN HOME PRODUCTS CORPORATION (US) 1984-06-12 US disclosed
US-4454291-A HYPOTENSIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1984-06-12 US disclosed
US-4396773-A 1,1'-[Dithiobis(2-alkyl-1-oxo-3,1-propanediyl)]-bis[2,3-dihydro-1H-indole-2-carboxylic acids and derivatives AMERICAN HOME PRODUCTS CORPORATION (US) 1983-08-02 US disclosed
US-4385180-A 10,10a-Dihydro-1H-thiozino[4,3-a,]-indole-1,4(3H)-diones AMERICAN HOME PRODUCTS CORPORATION (US) 1983-05-24 US disclosed
US-4350633-A ENZYME INHIBITORS, HYPOTENSIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1982-09-21 US disclosed
US-4303583-A 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones AMERICAN HOME PRODUCTS CORPORATION (US) 1981-12-01 US disclosed
EP-0024852-A1 2,3-Dihydro-1H-indole derivatives and intermediates therefor, processes for their preparation, pharmaceutical compositions containing these derivatives and their preparation AMERICAN HOME PRODUCTS CORPORATION (US) 1981-03-11 EP disclosed