Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 11/20 | 0.38 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.38 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 9/20 | 0.34 |
| ▸ | CA9 | Q16790 | 6/20 | 0.34 |
| ▸ | CA12 | O43570 | 6/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.33 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 4/20 | 0.32 |
| ▸ | CA4 | P22748 | 3/20 | 0.32 |
| ▸ | CA7 | P43166 | 3/20 | 0.32 |
| ▸ | CA5A | P35218 | 2/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7777711 | 0.83 | CA2 (0.45) | CA2PDIA6CA1CA9CA12 | |
| SCHEMBL1559677 | 0.78 | KDM4E (0.45) | CA2PDIA6KDM4EALDH1A1CA1 | |
| SCHEMBL9644228 | 0.78 | L3MBTL1 (0.46) | CA2PDIA6KDM4EALDH1A1CA1 | |
| SCHEMBL30069489 | 0.78 | KDM4E (0.45) | CA2PDIA6KDM4EALDH1A1CA1 | |
| SCHEMBL9174184 | 0.78 | CA2 (0.53) | CA2PDIA6KDM4EALDH1A1CA1 | |
| SCHEMBL23319859 | 0.78 | CA2 (0.53) | CA2ALDH1A1CA1CA9CA12 | |
| SCHEMBL27536370 | 0.78 | CA1 (0.37) | CA2PDIA6TET2CA1CA9 | |
| SCHEMBL4619403 | 0.77 | CA2 (0.42) | CA2PDIA6ALDH1A1CA1CA9 | |
| SCHEMBL29839131 | 0.77 | LMNA (0.45) | CA2CA1CA9CA12LDHA | |
| SCHEMBL7433447 | 0.77 | CA2 (0.42) | CA2KDM4ECA1CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786782-B1 | BISARYL-SULFONAMIDES | AMGEN INC (US) | 2010-03-31 | — | — | EP | disclosed |