Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911429 | 0.90 | KDM4E (0.61) | EGLN3KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL3257323 | 0.85 | EGLN3 (0.54) | EGLN3KDM4ETP53SMN1; SMN2KMT2A | |
| SCHEMBL3256900 | 0.85 | EGLN3 (0.48) | EGLN3KDM4ETP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL3140575 | 0.83 | KDM4E (0.48) | EGLN3KDM4ETP53SMN1; SMN2MEN1 | |
| SCHEMBL3260194 | 0.83 | EGLN3 (0.47) | EGLN3KDM4ETP53SMN1; SMN2MEN1 | |
| SCHEMBL3127230 | 0.82 | EGLN3 (0.56) | EGLN3KDM4ETP53SMN1; SMN2KMT2A | |
| SCHEMBL3132995 | 0.82 | EGLN3 (0.51) | EGLN3KDM4ETP53SMN1; SMN2MEN1 | |
| SCHEMBL3258148 | 0.82 | EGLN3 (0.50) | EGLN3KDM4ETP53SMN1; SMN2MEN1 | |
| SCHEMBL3256030 | 0.82 | EGLN3 (0.78) | EGLN3KDM4ETP53SMN1; SMN2MEN1 | |
| SCHEMBL3138489 | 0.81 | EGLN3 (0.65) | EGLN3KDM4ETP53SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059549-A1 | PROLYL HYDROXYLASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |