Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 8/20 | 0.42 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | F3 | P13726 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4253336 | 0.99 | DPP4 (0.43) | DPP4DPP8ABCB1DRD1DRD2 | |
| SCHEMBL3155041 | 0.90 | DPP4 (0.49) | DPP4DPP8MAPTHTR1ARAB9A | |
| SCHEMBL3144330 | 0.90 | DPP4 (0.49) | DPP4DPP8MAPTHTR1ARAB9A | |
| Hydrochloric Acid SCHEMBL4248376 | 0.89 | DPP4 (0.48) | DPP4DPP8MAPTHTR1ARAB9A | |
| SCHEMBL3149534 | 0.86 | DPP4 (0.47) | DPP4DPP8ABCB1MAPTHTR1A | |
| Hydrochloric Acid SCHEMBL4249209 | 0.85 | DPP4 (0.46) | DPP4DPP8MAPTHTR1ARAB9A | |
| SCHEMBL3149531 | 0.85 | DPP4 (0.46) | DPP4DPP8DRD1DRD2MAPT | |
| Hydrochloric Acid SCHEMBL4251956 | 0.85 | DPP4 (0.45) | DPP4DPP8DRD1DRD2MAPT | |
| SCHEMBL3149354 | 0.83 | HTR1A (0.52) | ABCB1DRD1DRD2CYP1A2CYP3A4 | |
| SCHEMBL3149736 | 0.83 | DPP4 (0.46) | DPP4DPP8ABCB1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036892-B1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-03-10 | — | — | EP | disclosed |
| EP-2036892-A1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-03-18 | — | — | EP | disclosed |