Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1164551 | 0.84 | — | — | |
| SCHEMBL358337 | 0.84 | — | — | |
| SCHEMBL15760567 | 0.82 | — | — | |
| SCHEMBL4407661 | 0.79 | TSHR (0.59) | TSHRMEN1KMT2AALDH1A1PDPK1 | |
| SCHEMBL13606400 | 0.79 | TSHR (0.59) | TSHRMEN1KMT2AALDH1A1PDPK1 | |
| SCHEMBL1318409 | 0.77 | ALDH1A1 (0.49) | TSHRMEN1KMT2AALDH1A1GAA | |
| SCHEMBL8283359 | 0.77 | KMT2A (0.49) | TSHRMEN1KMT2AALDH1A1GAA | |
| SCHEMBL25017479 | 0.77 | TSHR (0.58) | TSHRMEN1KMT2AALDH1A1PDPK1 | |
| SCHEMBL1009529 | 0.77 | TSHR (1.00) | TSHRMEN1KMT2AALDH1A1GAA | |
| SCHEMBL13890042 | 0.76 | TSHR (0.44) | TSHRMEN1KMT2AALDH1A1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699800-B1 | BICYCLIC HETEROCYCLIC P-38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-02-10 | — | — | EP | disclosed |
| US-20090264409-A1 | Bicyclic Heterocyclic p-38 Kinase Inhibitors | DONG QING | 2009-10-22 | — | — | US | disclosed |
| US-7569571-B2 | Substituted pyrazolo [3,4-d]pyrimidines as cytokine modulators | NOVARTIS AG (CH) | 2009-08-04 | — | — | US | disclosed |
| US-20070142405-A1 | Such as N-cyclopropyl-4-methyl-3-(4-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-benzamide; for inhibiting p38 kinase mediated diseases and disorders such as inflammatory diseases | TRIAD THERAPEUTICS, INC. | 2007-06-21 | — | — | US | disclosed |
| CN-1898243-A | Bicyclic heterocyclic p-38 kinase inhibitors | NOVARTIS AG (CH) | 2007-01-17 | — | — | CN | disclosed |
| EP-1699800-A2 | BICYCLIC HETEROCYCLIC P-38 KINASE INHIBITORS | Novartis AG (CH) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005063766-A2 | BICYCLIC HETEROCYCLIC P-38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264409-A1 | Bicyclic Heterocyclic p-38 Kinase Inhibitors | MAPK8, MAP3K8, MAPKAPK2 | TSHR 4247/4885MEN1 4653/4885KMT2A 3361/4885 |
| US-20070142405-A1 | Such as N-cyclopropyl-4-methyl-3-(4-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-benzamide; for inhibiting p38 kinase mediated diseases and disorders such as inflammatory diseases | MAPK1, MAP3K8, MAP3K1 | TSHR 4071/4885MEN1 4824/4885KMT2A 2328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.