Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.47 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741387 | 0.81 | GPBAR1 (0.57) | AXLKDM4ENR4A2GPBAR1PDGFRB | |
| SCHEMBL4742362 | 0.81 | KDM4E (0.45) | AXLKDM4ENR4A2GAAOPRK1 | |
| SCHEMBL4741381 | 0.77 | ELANE (0.45) | AXLKDM4ENR4A2ALDH1A1GPBAR1 | |
| SCHEMBL4460248 | 0.75 | KDM4E (0.50) | AXLKDM4EALDH1A1GLAGAA | |
| SCHEMBL3263651 | 0.74 | KDM4E (0.49) | CSNK2A2CSNK2BAXLKDM4ENR4A2 | |
| SCHEMBL22717316 | 0.74 | ALDH1A1 (0.47) | KDM4EALDH1A1GLAGAA | |
| SCHEMBL3262648 | 0.74 | CSNK2A2 (0.46) | CSNK2A2CSNK2BGPBAR1PDGFRBPDGFRA | |
| SCHEMBL3262682 | 0.74 | CSNK2A2 (0.46) | CSNK2A2CSNK2BGPBAR1PDGFRBPDGFRA | |
| SCHEMBL1177963 | 0.71 | CHEK2 (0.52) | KDM4EALDH1A1PDGFRBPDGFRACHEK2 | |
| SCHEMBL23043865 | 0.70 | KDM4E (0.57) | AXLKDM4EALDH1A1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010016846-A1 | HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010016846-A1 | HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-02-11 | — | — | WO | disclosed |
| US-20090054304-A1 | HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-02-26 | — | — | US | disclosed |
| US-20090054304-A1 | HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-02-26 | — | — | US | disclosed |
| US-20090054304-A1 | HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054304-A1 | HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE | GPBAR1, GPR119, PLAAT5 | CSNK2A2 2885/4885CSNK2B 3273/4885AXL 3955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.