Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 4/20 | 0.46 |
| ▸ | SETD1B | Q9UPS6 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14455124 | 0.87 | FBP1 (0.50) | STAT3FBP1CCNE1CDK2CDK5 | |
| SCHEMBL3263056 | 0.87 | NPC1 (0.48) | STAT3FBP1CCNE1CDK2CDK5 | |
| SCHEMBL3259757 | 0.87 | STAT3 (0.47) | STAT3ALDH1A1RAB9AGAAL3MBTL1 | |
| SCHEMBL13524016 | 0.86 | ALDH1A1 (0.49) | STAT3FBP1SETD1BCCNE1CDK2 | |
| SCHEMBL3258310 | 0.83 | NPC1 (0.51) | STAT3FBP1CCNE1CDK2CDK5 | |
| SCHEMBL3175859 | 0.82 | STAT3 (0.67) | STAT3FBP1CCNE1CDK2CDK5 | |
| SCHEMBL10201493 | 0.81 | FBP1 (0.58) | STAT3FBP1CCNE1CDK2CDK5 | |
| SCHEMBL13524020 | 0.76 | RAB9A (0.51) | STAT3FBP1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3261622 | 0.74 | LRRK2 (0.46) | FBP1SETD1BALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL720134 | 0.73 | SMN1; SMN2 (0.54) | FBP1SETD1BCCNE1CDK2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789040-B1 | HALOGENATED BENZAMIDE DERIVATIVES | ROMARK LAB LC (US) | 2015-12-23 | — | — | EP | claimed |
| EP-1789040-A4 | HALOGENATED BENZAMIDE DERIVATIVES | ROMARK LAB LC (US) | 2009-09-02 | — | — | EP | claimed |
| US-7550493-B2 | Halogenated benzamide derivatives | ROMARK LABORATORIES, LC (US) | 2009-06-23 | — | — | US | claimed |
| US-20080097106-A1 | HALOGENATED BENZAMIDE DERIVATIVES | ROMARK LABORATORIES L.C. . (US) | 2008-04-24 | — | — | US | claimed |
| US-7285567-B2 | Halogenated benzamide derivatives | ROMARK LABORATORIES, L.C. (US) | 2007-10-23 | — | — | US | claimed |
| EP-1789040-A2 | HALOGENATED BENZAMIDE DERIVATIVES | Romark Laboratories, L.C. (US) | 2007-05-30 | — | — | EP | claimed |
| US-20060089396-A1 | Halogenated benzamide derivatives | U.S. BANK NATIONAL ASSOCIATION | 2006-04-27 | — | — | US | claimed |
| WO-2006031566-A2 | HALOGENATED BENZAMIDE DERIVATIVES | ROMARK LABORATORIES, L.C. (US) | 2006-03-23 | — | — | WO | claimed |
| EP-1789040-B1 | HALOGENATED BENZAMIDE DERIVATIVES | ROMARK LAB LC (US) | 2015-12-23 | — | — | EP | disclosed |
| US-7645783-B2 | Halogenated benzamide derivatives | ROMARK LABORATORIES L.C. (US) | 2010-01-12 | — | — | US | disclosed |
| EP-1789040-A4 | HALOGENATED BENZAMIDE DERIVATIVES | ROMARK LAB LC (US) | 2009-09-02 | — | — | EP | disclosed |
| US-7550493-B2 | Halogenated benzamide derivatives | ROMARK LABORATORIES, LC (US) | 2009-06-23 | — | — | US | disclosed |
| US-20080097106-A1 | HALOGENATED BENZAMIDE DERIVATIVES | ROMARK LABORATORIES L.C. . (US) | 2008-04-24 | — | — | US | disclosed |
| US-20080096941-A1 | HALOGENATED BENZAMIDE DERIVATIVES | ROMARK LABORATORIES L.C. (US) | 2008-04-24 | — | — | US | disclosed |
| US-7285567-B2 | Halogenated benzamide derivatives | ROMARK LABORATORIES, L.C. (US) | 2007-10-23 | — | — | US | disclosed |
| EP-1789040-A2 | HALOGENATED BENZAMIDE DERIVATIVES | Romark Laboratories, L.C. (US) | 2007-05-30 | — | — | EP | disclosed |
| US-20060089396-A1 | Halogenated benzamide derivatives | U.S. BANK NATIONAL ASSOCIATION | 2006-04-27 | — | — | US | disclosed |
| WO-2006031566-A2 | HALOGENATED BENZAMIDE DERIVATIVES | ROMARK LABORATORIES, L.C. (US) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080097106-A1 | HALOGENATED BENZAMIDE DERIVATIVES | CBR3, CBR1, HDAC3 | STAT3 4027/4885FBP1 3380/4885SETD1B 1601/4885 |
| US-20060089396-A1 | Halogenated benzamide derivatives | CBR3, CBR1, HDAC3 | STAT3 3774/4885FBP1 3177/4885SETD1B 1481/4885 |
| US-20080096941-A1 | HALOGENATED BENZAMIDE DERIVATIVES | CBR3, H1-3, BCL3 | STAT3 3680/4885FBP1 3332/4885SETD1B 2177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.