Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.42 |
| ▸ | HTR3B | O95264 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 7/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814733 | 0.86 | ALDH1A1 (0.41) | KMT2ASMN1; SMN2NOTUMQPCTALDH1A1 | |
| SCHEMBL7823338 | 0.86 | NOTUM (0.40) | KMT2ASMN1; SMN2NOTUMQPCTALDH1A1 | |
| SCHEMBL1843567 | 0.85 | ALDH1A1 (0.43) | HPGDKMT2ASMN1; SMN2NOTUMQPCT | |
| SCHEMBL3573592 | 0.84 | NOTUM (0.38) | KMT2ASMN1; SMN2NOTUMQPCTALDH1A1 | |
| SCHEMBL3575078 | 0.80 | NOTUM (0.35) | SMN1; SMN2NOTUMQPCT | |
| SCHEMBL3578214 | 0.79 | MAPK1 (0.40) | SIGMAR1KMT2ASMN1; SMN2NOTUMQPCT | |
| SCHEMBL2724582 | 0.75 | ALDH1A1 (0.38) | KMT2ASMN1; SMN2NOTUMALDH1A1 | |
| SCHEMBL3586944 | 0.75 | ALDH1A1 (0.33) | NOTUMQPCTALDH1A1 | |
| SCHEMBL3572019 | 0.75 | IDH1 (0.32) | NOTUMQPCT | |
| SCHEMBL3578652 | 0.75 | QPCT (0.32) | NOTUMQPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254892-B1 | BICYCLIC NITROIMIDAZOLES COVALENTLY LINKED TO SUBSTITUTED PHENYL OXAZOLIDINONES | GLOBAL ALLIANCE FOR TB DRUG DEV (US) | 2014-04-23 | — | — | EP | disclosed |
| EP-1804799-B1 | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors | XENON PHARMACEUTICALS INC (CA) | 2013-08-21 | — | — | EP | disclosed |
| EP-2254892-A1 | BICYCLIC NITROIMIDAZOLES COVALENTLY LINKED TO SUBSTITUTED PHENYL OXAZOLIDINONES | Global Alliance For Tb Drug Development (US) | 2010-12-01 | — | — | EP | disclosed |
| US-7666864-B2 | Bicyclic nitroimidazole-substituted phenyl oxazolidinones | GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT (US) | 2010-02-23 | — | — | US | disclosed |
| US-20090281088-A1 | BICYCLIC NITROIMIDAZOLE-SUBSTITUTED PHENYL OXAZOLIDINONES | GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT (US) | 2009-11-12 | — | — | US | disclosed |
| WO-2009120789-A1 | BICYCLIC NITROIMIDAZOLES COVALENTLY LINKED TO SUBSTITUTED PHENYL OXAZOLIDINONES | GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT (US) | 2009-10-01 | — | — | WO | disclosed |
| US-20060293307-A1 | Oxazolidinone derivatives as antimicrobials | RANBAXY LABORATORIES LIMITED (IN) | 2006-12-28 | — | — | US | disclosed |
| EP-1542696-A4 | OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS | RANBAXY LAB LTD (IN) | 2006-08-02 | — | — | EP | disclosed |
| WO-2006043121-A1 | OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS | RANBAXY LABORATORIES LIMITED (IN) | 2006-04-27 | — | — | WO | disclosed |
| CN-1668308-A | Oxazolidinone derivatives as antimicrobials | RANBAXY LAB LTD (IN) | 2005-09-14 | — | — | CN | disclosed |
| US-5977373-A | Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents | PHARMACIA & UPJOHN COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0730591-B1 | ESTERS OF SUBSTITUTED-HYDROXYACETYL PIPERAZINE PHENYL OXAZOLIDINONES | UPJOHN CO (US) | 1999-07-14 | — | — | EP | disclosed |
| CN-1206410-A | Azolyl piperazinyl phenyl oxazolidinone antimicrobials | UPJOHN CO (US) | 1999-01-27 | — | — | CN | disclosed |
| CN-1206410-A | Azolyl piperazinyl phenyl oxazolidinone antimicrobials | UPJOHN CO (US) | 1999-01-27 | — | — | CN | disclosed |
| EP-0883611-A1 | AZOLYL PIPERAZINYL PHENYL OXAZOLIDINONE ANTIMICROBIALS | PHARMACIA & UPJOHN COMPANY (US) | 1998-12-16 | — | — | EP | disclosed |
| US-5736545-A | ADMINISTERING TO TREAT BACTERIAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-07 | — | — | US | disclosed |
| US-5736545-A | ADMINISTERING TO TREAT BACTERIAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-07 | — | — | US | disclosed |
| WO-1997030981-A1 | AZOLYL PIPERAZINYL PHENYL OXAZOLIDINONE ANTIMICROBIALS | PHARMACIA & UPJOHN COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |
| EP-0730591-A1 | ESTERS OF SUBSTITUTED-HYDROXYACETYL PIPERAZINE PHENYL OXAZOLIDINONES | PHARMACIA & UPJOHN COMPANY (US) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014684-A1 | ESTERS OF SUBSTITUTED-HYDROXYACETYL PIPERAZINE PHENYL OXAZOLIDINONES | THE UPJOHN COMPANY (US) | 1995-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293307-A1 | Oxazolidinone derivatives as antimicrobials | OXA1L, PDK4, SDHA | SIGMAR1 2456/4885HTR3E 4605/4885HTR3B 4622/4885 |
| US-20090281088-A1 | BICYCLIC NITROIMIDAZOLE-SUBSTITUTED PHENYL OXAZOLIDINONES | O60361, OXA1L, TBCD | SIGMAR1 2659/4885HTR3E 4516/4885HTR3B 3743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.