Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11218137 | 0.86 | PTPN1 (0.57) | PTPN1ABCB1 | |
| SCHEMBL11050071 | 0.84 | PTPN1 (0.49) | MTNR1AMTNR1BPTPN1 | |
| SCHEMBL13986657 | 0.83 | MTNR1A (0.58) | MTNR1AMTNR1BPTPN1ABCB1 | |
| SCHEMBL4808177 | 0.76 | PTPN1 (0.53) | MTNR1AMTNR1BPTPN1ABCB1 | |
| SCHEMBL669127 | 0.76 | PTPN1 (0.54) | MTNR1AMTNR1BPTPN1 | |
| SCHEMBL5764063 | 0.76 | PTPN1 (0.83) | PTPN1 | |
| SCHEMBL2985777 | 0.76 | PTPN1 (0.53) | PTPN1 | |
| SCHEMBL14387039 | 0.75 | PTPN1 (0.50) | PTPN1 | |
| SCHEMBL6528889 | 0.75 | TLR8 (0.48) | PTPN1 | |
| SCHEMBL13049676 | 0.75 | PTPN1 (0.55) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354861-A | Binds to antiestrogen binding sites; antiproliferative activity | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 1994-10-11 | — | — | US | claimed |
| US-20100267822-A1 | AURONES AS ESTROGEN RECEPTOR MODULATORS AND THEIR USE IN SEX HORMONE DEPENDENT DISEASES | BIOTROPICS MALAYSIA BERHAD (MY) | 2010-10-21 | — | — | US | disclosed |
| WO-2010110647-A1 | AURONES AS ESTROGEN RECEPTOR MODULATORS AND THEIR USE IN SEX HORMONE DEPENDENT DISEASES | BIOTROPICS MALAYSIA BERHAD (MY) | 2010-09-30 | — | — | WO | disclosed |
| EP-0838461-B1 | Substituted 2,3-aryl-benzothiophene compounds having estrogenic activity | LILLY CO ELI (US) | 2003-09-03 | — | — | EP | disclosed |
| US-5459139-A | Antitumor agents, anticholesterol agents, antiestrogens, treatment of breast cancer | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 1995-10-17 | — | — | US | disclosed |
| US-5459139-A | Antitumor agents, anticholesterol agents, antiestrogens, treatment of breast cancer | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 1995-10-17 | — | — | US | disclosed |
| US-5459139-A | Antitumor agents, anticholesterol agents, antiestrogens, treatment of breast cancer | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 1995-10-17 | — | — | US | disclosed |
| US-5354861-A | Binds to antiestrogen binding sites; antiproliferative activity | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 1994-10-11 | — | — | US | disclosed |
| US-5354861-A | Binds to antiestrogen binding sites; antiproliferative activity | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 1994-10-11 | — | — | US | disclosed |
| US-5354861-A | Binds to antiestrogen binding sites; antiproliferative activity | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 1994-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267822-A1 | AURONES AS ESTROGEN RECEPTOR MODULATORS AND THEIR USE IN SEX HORMONE DEPENDENT DISEASES | SHBG, GPER1, ESR2 | MTNR1A 129/4885MTNR1B 317/4885PTPN1 3943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.