Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3267568 | 0.85 | AKT2 (0.56) | LRRK2POLBAKT2CHEK1KMT2A | |
| SCHEMBL3390214 | 0.83 | IKBKB (0.55) | LRRK2TDP1POLBAKT2CHEK1 | |
| SCHEMBL3263313 | 0.82 | ALK (0.47) | LRRK2TDP1AKT2CHEK1MKNK1 | |
| SCHEMBL3261336 | 0.81 | HSP90AA1 (0.48) | LRRK2TDP1KMT2ALMNAIKBKB | |
| SCHEMBL3262839 | 0.74 | MAPT (0.49) | LMNAALDH1A1 | |
| SCHEMBL28979838 | 0.73 | AKT2 (0.68) | LRRK2AKT2CHEK1IMPDH2KMT2A | |
| SCHEMBL3259645 | 0.70 | KMT2A (0.50) | LRRK2KMT2ALMNAALDH1A1HSD17B10 | |
| SCHEMBL14519374 | 0.67 | LRRK2 (0.60) | LRRK2AKT2CHEK1KMT2AMKNK1 | |
| SCHEMBL5450218 | 0.67 | LRRK2 (0.56) | LRRK2 | |
| SCHEMBL3263794 | 0.66 | LRRK2 (0.45) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015657-A2 | NEW ALKOXYPYRAZOLES | INSTITUT PASTEUR (FR) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015657-A2 | NEW ALKOXYPYRAZOLES | INSTITUT PASTEUR (FR) | 2010-02-11 | — | — | WO | disclosed |
| EP-2151433-A1 | Alkoxypyrazoles and the process for their preparation | Institut Pasteur (FR) | 2010-02-10 | — | — | EP | disclosed |
| EP-2151433-A1 | Alkoxypyrazoles and the process for their preparation | Institut Pasteur (FR) | 2010-02-10 | — | — | EP | disclosed |