Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3267568 | 0.83 | AKT2 (0.56) | LRRK2PIM1CHEK1AURKACSF1R | |
| SCHEMBL3261526 | 0.82 | LRRK2 (0.51) | LRRK2CHEK1MKNK1MKNK2ALDH1A1 | |
| SCHEMBL17156128 | 0.75 | LRRK2 (0.42) | ALKLRRK2PIM1CHEK1AURKA | |
| SCHEMBL3262839 | 0.75 | MAPT (0.49) | ROCK1DYRK1ACLK4ALDH1A1LMNA | |
| SCHEMBL3390214 | 0.75 | IKBKB (0.55) | LRRK2CHEK1CDK8IKBKEMKNK1 | |
| SCHEMBL2322659 | 0.74 | AKT2 (0.67) | ALKLRRK2PIM1CHEK1AURKA | |
| SCHEMBL3261336 | 0.74 | HSP90AA1 (0.48) | LRRK2IKBKECYP1A2ALDH1A1CYP3A4 | |
| SCHEMBL3261292 | 0.69 | ALDH1A1 (0.46) | MKNK1MKNK2ALDH1A1 | |
| SCHEMBL7534819 | 0.69 | MKNK1 (0.45) | ALKMKNK1MKNK2CYP1A2CYP2A6 | |
| SCHEMBL3259645 | 0.69 | KMT2A (0.50) | LRRK2GSK3BALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015657-A2 | NEW ALKOXYPYRAZOLES | INSTITUT PASTEUR (FR) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015657-A2 | NEW ALKOXYPYRAZOLES | INSTITUT PASTEUR (FR) | 2010-02-11 | — | — | WO | disclosed |
| EP-2151433-A1 | Alkoxypyrazoles and the process for their preparation | Institut Pasteur (FR) | 2010-02-10 | — | — | EP | disclosed |
| EP-2151433-A1 | Alkoxypyrazoles and the process for their preparation | Institut Pasteur (FR) | 2010-02-10 | — | — | EP | disclosed |