Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3258485 | 0.81 | KDM4E (0.40) | CYP2C19CYP3A4KDM4EMAPTALOX15 | |
| SCHEMBL8525246 | 0.79 | ALDH1A1 (0.35) | CYP2C19CYP3A4KDM4EMAPTALOX15 | |
| SCHEMBL10452869 | 0.78 | CYP2C19 (0.36) | CYP2C19CYP3A4KDM4EMAPTALOX15 | |
| SCHEMBL11766335 | 0.78 | CYP2D6 (0.37) | CYP2C19CYP3A4KDM4EMAPTALOX15 | |
| SCHEMBL488830 | 0.76 | CYP2C19 (0.39) | CYP2C19CYP3A4KDM4EMAPTALOX15 | |
| SCHEMBL30104387 | 0.76 | CYP3A4 (0.33) | CYP2C19CYP3A4KDM4EMAPTALOX15 | |
| SCHEMBL30104386 | 0.76 | CYP3A4 (0.33) | CYP2C19CYP3A4KDM4EMAPTALOX15 | |
| SCHEMBL15295377 | 0.76 | CYP3A4 (0.33) | CYP2C19CYP3A4KDM4EMAPTALOX15 | |
| SCHEMBL6889278 | 0.76 | MIF (0.34) | CYP2C19CYP3A4KDM4EMAPTALOX15 | |
| SCHEMBL1047388 | 0.76 | CYP2C19 (0.35) | CYP2C19CYP3A4KDM4EMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5001148-A | Mevinic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1991-03-19 | — | — | US | claimed |
| EP-0401784-A1 | Mevinic acid derivatives | E.R. Squibb & Sons, Inc. (US) | 1990-12-12 | — | — | EP | claimed |
| US-3960886-A | Substituted N-arylanilines | STERLING DRUG INC. (US) | 1976-06-01 | — | — | US | claimed |
| EP-2157081-A1 | Indolinones substituted in six locations, their manufacture and their application as medicine | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2010-02-24 | — | — | EP | disclosed |
| US-5001148-A | Mevinic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1991-03-19 | — | — | US | disclosed |
| US-5001148-A | Mevinic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1991-03-19 | — | — | US | disclosed |
| EP-0401784-A1 | Mevinic acid derivatives | E.R. Squibb & Sons, Inc. (US) | 1990-12-12 | — | — | EP | disclosed |
| EP-0401784-A1 | Mevinic acid derivatives | E.R. Squibb & Sons, Inc. (US) | 1990-12-12 | — | — | EP | disclosed |
| US-4327098-A | Pharmaceutical compositions useful in the treatment of cardiovascular hypertension and containing 4-substituted-2-iminoimadazolidine compounds | A. H. ROBINS COMPANY, INC. (US) | 1982-04-27 | — | — | US | disclosed |
| US-4327108-A | Methods useful in the treatment of cardiac arrhythmia using 4-substituted-2-iminoimidazolidine compounds | A. H. ROBINS COMPANY, INC. (US) | 1982-04-27 | — | — | US | disclosed |
| US-4327107-A | Method useful in the treatment of sugar cataracts using 4-substituted-2-iminoimidazolidine compounds | A. H. ROBINS COMPANY, INC. (US) | 1982-04-27 | — | — | US | disclosed |
| US-4288447-A | Antihyperglycemic 4-substituted 2-iminoimidazolidine compositions | A. H. ROBINS COMPANY, INC. (US) | 1981-09-08 | — | — | US | disclosed |
| US-4288591-A | ANTIINFLAMMATORY, HYPOTENSIVE, HYPOGLYCEMIC | A. H. ROBINS COMPANY, INC. (US) | 1981-09-08 | — | — | US | disclosed |
| US-4247705-A | HYPOTENSIVE, HYPOGLYCEMIC, ANTIINFLAMMATORY | A. H. ROBINS COMPANY, INC. (US) | 1981-01-27 | — | — | US | disclosed |
| US-4195092-A | INSECTICIDES FOR TREATING MEXICAN BEAN BEETLE | ELI LILLY AND COMPANY (US) | 1980-03-25 | — | — | US | disclosed |