Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.48 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263282 | 0.84 | GPX4 (0.58) | MEN1KMT2ACACNA1BCACNA2D1CACNB1 | |
| SCHEMBL10371605 | 0.82 | ACHE (0.54) | ACHEMEN1KMT2ACACNA1BATM | |
| SCHEMBL3263615 | 0.81 | CHRM2 (0.58) | MEN1KMT2ACACNA1BATMCACNA2D1 | |
| SCHEMBL5740502 | 0.76 | ACHE (0.51) | ACHEMEN1KMT2ACACNA1BATM | |
| SCHEMBL917471 | 0.76 | CACNA2D1 (0.59) | ACHEMEN1KMT2ACACNA1BATM | |
| SCHEMBL16227288 | 0.76 | ACHE (0.59) | ACHEMEN1KMT2ACACNA1BATM | |
| SCHEMBL9813068 | 0.76 | ACHE (0.59) | ACHEMEN1KMT2ACACNA1BATM | |
| SCHEMBL7395502 | 0.76 | CYP2D6 (0.66) | ACHEMEN1KMT2ACACNA1BCACNA2D1 | |
| SCHEMBL3261754 | 0.75 | ACHE (0.54) | ACHEMEN1KMT2ACACNA1BATM | |
| SCHEMBL14280201 | 0.75 | ACHE (0.71) | ACHEMEN1KMT2AOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146991-B1 | TRIAZOLOPYRIDINE CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-07-28 | — | — | EP | disclosed |
| EP-2146991-A2 | TRIAZOLOPYRIDINE CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008145842-A2 | TRIAZOLOPYRIDINE CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2008-12-04 | — | — | WO | disclosed |