Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.46 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5051944 | 0.83 | CHRM2 (0.55) | MEN1KMT2ALMNAOPRM1CYP2D6 | |
| SCHEMBL4014691 | 0.80 | MAPT (0.49) | LMNAMAPTMAPK1NPSR1KDM4E | |
| SCHEMBL3261754 | 0.79 | ACHE (0.54) | ACHEMEN1KMT2ALMNAOPRM1 | |
| SCHEMBL3261748 | 0.76 | ACHE (0.54) | ACHEMEN1KMT2ALMNAOPRM1 | |
| SCHEMBL917471 | 0.73 | CACNA2D1 (0.59) | ACHEMEN1KMT2ACACNA1BATM | |
| SCHEMBL7267071 | 0.73 | ACHE (0.55) | ACHEMEN1KMT2ALMNAOPRM1 | |
| SCHEMBL9813068 | 0.73 | ACHE (0.59) | ACHEMEN1KMT2ALMNAOPRM1 | |
| SCHEMBL16227288 | 0.73 | ACHE (0.59) | ACHEMEN1KMT2ALMNAOPRM1 | |
| SCHEMBL7395502 | 0.73 | CYP2D6 (0.66) | ACHEMEN1KMT2ALMNAOPRM1 | |
| SCHEMBL9279975 | 0.73 | LMNA (0.34) | LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660454-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS | Vernalis (R&D) Limited (GB) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005005392-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS | IONIX PHARMACEUTICALS LIMITED (GB) | 2005-01-20 | — | — | WO | disclosed |