Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | GABRP | O00591 | 5/20 | 0.38 |
| ▸ | GABRD | O14764 | 5/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.38 |
| ▸ | GABRE | P78334 | 5/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 5/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19438800 | 0.85 | NOTUM (0.49) | NOTUMGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL18432370 | 0.79 | NOTUM (0.42) | NOTUMGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5173280 | 0.75 | GABRP (0.42) | NOTUMGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL3493577 | 0.72 | NOTUM (0.64) | NOTUMALDH1A1TDP1RAB9A | |
| SCHEMBL8519956 | 0.71 | NOTUM (0.54) | NOTUMALDH1A1TDP1CNR2CNR1 | |
| SCHEMBL5068788 | 0.70 | CNR2 (0.56) | NOTUMALDH1A1TDP1FABP4CNR2 | |
| SCHEMBL2804808 | 0.70 | NOTUM (0.41) | NOTUMGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL21408508 | 0.68 | NOTUM (0.40) | NOTUMGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5776620 | 0.67 | MEN1 (0.42) | ALDH1A1TDP1L3MBTL1CNR2NPC1 | |
| SCHEMBL13522478 | 0.67 | POLB (0.44) | ALDH1A1L3MBTL1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7671049-B2 | Pyrrole based inhibitors of glycogen synthase kinase 3 | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-20070244109-A1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2007-10-18 | — | — | US | disclosed |
| US-7250443-B2 | Pyrrole based inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION (US) | 2007-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244109-A1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | GSK3B, GSK3A, PYGB | NOTUM 731/4885GABRP 1317/4885GABRD 3615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.